4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzene-1-sulfonyl chloride , 98% , 139756-22-2

CAS NO.：139756-22-2

Empirical Formula: C17H19ClN4O4S

Molecular Weight: 410.88

MDL number: MFCD09753597

PRODUCT Properties

• Melting point: 180-182°C
• Density: 1.48±0.1 g/cm3(Predicted)
• storage temp.: Inert atmosphere,2-8°C
• solubility: Chloroform (Slightly), Methanol (Slightly, Heated)
• form: Solid
• pka: 9.87±0.20(Predicted)
• color: White to Pale Beige
• Stability: Moisture Sensitive
• InChI: InChI=1S/C17H19ClN4O4S/c1-4-6-12-14-15(22(3)21-12)17(23)20-16(19-14)11-9-10(27(18,24)25)7-8-13(11)26-5-2/h7-9H,4-6H2,1-3H3,(H,19,20,23)
• InChIKey: RVVOSOSBFSYZDM-UHFFFAOYSA-N
• SMILES: C1(S(Cl)(=O)=O)=CC=C(OCC)C(C2NC(=O)C3N(C)N=C(CCC)C=3N=2)=C1
• CAS DataBase Reference: 139756-22-2

Description and Uses

Sildenafil chlorosulfonyl is a synthetic intermediate in the synthesis of the phosphodiesterase 5 (PDE5) inhibitor sildenafil. It is also a potential impurity found in commercial preparations of sildenafil.

The compound Sildenafil Chlorosulfonyl Impurity (139756-22-2) is a derivative of Sildenafil. It is widely used in the treatment of pulmonary hypertension as it is capable of inhibiting cGMP and acts as a potent selective inhibitor of PDE5.

Safety

• Symbol(GHS): GHS05
• Signal word: Danger
• Hazard statements: H314
• Precautionary statements: P280-P301+P330+P331-P303+P361+P353
• HS Code: 2933599590