(2E)-4-(dimethylamino)but-2-enoic acid hydrochloride , 97% , 848133-35-7

CAS NO.：848133-35-7

Empirical Formula: C6H12ClNO2

Molecular Weight: 165.62

MDL number: MFCD03695466

EINECS: 617-631-8

PRODUCT Properties

• Melting point: 162 °C
• storage temp.: Inert atmosphere,Room Temperature
• solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
• form: Solid
• color: White to Off-White
• InChI: InChI=1S/C6H11NO2.ClH/c1-7(2)5-3-4-6(8)9;/h3-4H,5H2,1-2H3,(H,8,9);1H/b4-3+
• InChIKey: UUHNQHFOIVLAQX-BJILWQEISA-N
• SMILES: C(/CN(C)C)=C\C(=O)O.Cl
• CAS DataBase Reference: 848133-35-7(CAS DataBase Reference)

Description and Uses

trans-4-Dimethylaminocrotonic acid hydrochloride is a very important pharmaceutical intermediate and is an essential part of the structure of the anti-tumour drugs afatinib and neratinib. It is also an important organic synthesis reagent for the preparation of novel pyrazole derivatives and 6-heterocycloalkyl quinazoline derivatives.

trans 4-Dimethylaminocrotonic acid HCl is a reagent used in the preparation of tyrosine kinase inhibiting antitumor agents.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H332-H335
• Precautionary statements: P261-P280-P305+P351+P338
• HS Code: 2922498590