Enalapril Maleate , ≥98% , 76095-16-4

Synonym(s):
(S)-N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-Ala-Pro maleate salt;Enalapril maleate salt

CAS NO.：76095-16-4

Empirical Formula: C24H32N2O9

Molecular Weight: 492.52

MDL number: MFCD00133304

EINECS: 278-375-7

PRODUCT Properties

• Melting point: 143-144,5°C
• Boiling point: 0°C
• alpha: D25 -42.2° (c = 1 in methanol)
• Flash point: 0°C
• storage temp.: 2-8°C
• solubility: methanol: ≥50 mg/mL, clear, colorless to yellow
• pka: pKa1 3.0; pKa2 (25°) 5.4
• form: powder
• color: white to off-white
• Water Solubility: Soluble in water, methanol, and ethanol.
• λmax: 208nm(MeOH)(lit.)
• Merck: 14,3567
• BCS Class: 1 (LogP), 3 (CLogP)
• InChIKey: OYFJQPXVCSSHAI-QFPUQLAESA-N

Description and Uses

Enalapril maleate is the second angiotensin converting enzyme inhibitor to reach the marketplace. Like captopril, the first entry in this area, enalapril is useful in the treatment of hypertension and congestive heart failure. It has a longer effective half-life than captopril, allowing once or twice-daily dosing, and appears to have a somewhat lower incidence of side effects.

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Safety

• Symbol(GHS): GHS08
• Signal word: Warning
• Hazard statements: H361fd
• Precautionary statements: P201-P202-P280-P308+P313-P405-P501
• Hazard Codes: Xi,Xn
• Risk Statements: 36/37/38-62-63
• Safety Statements: 22-24/25-36/37-26
• RIDADR: 3077
• WGK Germany: 2
• RTECS: TW3666000
• HS Code: 29339900
• Toxicity: LD50 oral in rat: 2973mg/kg