A3971212
Ethionamide , 98% , 536-33-4
Synonym(s):
2-Ethyl-4-pyridinecarbothioamide;Ethionamide
CAS NO.：536-33-4
Empirical Formula: C8H10N2S
Molecular Weight: 166.24
MDL number: MFCD00057361
EINECS: 208-628-9
| Pack Size | Price | Stock | Quantity |
| 5G | RMB104.00 | In Stock |
|
| 25G | RMB364.00 | In Stock |
|
| 100G | RMB1041.60 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 164 °C |
| Boiling point: | 167 °C / 1mmHg |
| Density | 1.1332 (rough estimate) |
| refractive index | 1.5500 (estimate) |
| Flash point: | >110°(230°F) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | pKa 4.37(H2O t=25.0 I=0.025) (Uncertain) |
| color | Yellow |
| Water Solubility | Soluble in DMSO. Sparingly soluble in water |
| Merck | 14,3737 |
| BCS Class | 3/1 |
| InChIKey | AEOCXXJPGCBFJA-UHFFFAOYSA-N |
Description and Uses
Ethionamide is an antimycobacterial compound that is active against M. tuberculosis (MICs = 0.3-1.25 μg/ml). It is activated via oxidation by flavin monooxygenase and inhibits the InhA enzyme involved in mycolic acid biosynthesis. Formulations containing ethionamide have been used in the second-line treatment of multi-drug resistant tuberculosis.
Antibacterial (tuberculostatic).
Safety
| Symbol(GHS) |   GHS07,GHS08 |
| Signal word | Warning |
| Hazard statements | H302-H361 |
| Precautionary statements | P280-P301+P312+P330 |
| Hazard Codes | Xn |
| Risk Statements | 22-63 |
| Safety Statements | 36/37 |
| WGK Germany | 3 |
| RTECS | NS0350000 |
| HS Code | 29333990 |
| Toxicity | LD50 oral in rat: 1320mg/kg |
