(±)-Epichlorohydrin , AR , 106-89-8
Synonym(s):
(±)-2-(Chloromethyl)oxirane;1-Chloro-2,3-epoxypropane
CAS NO.：106-89-8
Empirical Formula: C3H5ClO
Molecular Weight: 92.52
MDL number: MFCD00005132
EINECS: 203-439-8
PRODUCT Properties
| Melting point: | -57 °C |
| alpha | -1～+1°(D/20℃)(c=1,CH3OH) |
| Boiling point: | 115-117 °C(lit.) |
| Density | 1.183 g/mL at 25 °C(lit.) |
| vapor density | 3.2 (vs air) |
| vapor pressure | 13.8 mm Hg ( 21.1 °C) |
| refractive index | n |
| Flash point: | 93 °F |
| storage temp. | Store below +30°C. |
| solubility | 65.9g/l |
| form | Liquid |
| color | APHA: ≤20 |
| Specific Gravity | 1.183 (20/4℃) |
| Odor | Pungent, garlic; sweet, pungent; like chloroform. |
| explosive limit | 3.8-21%(V) |
| Water Solubility | 6 g/100 mL (10 ºC) |
| FreezingPoint | -57.2℃ |
| Merck | 14,3611 |
| BRN | 79785 |
| Henry's Law Constant | 3.42(x 10-5 atm?m3/mol) at 25 °C (static headspace-GC, Welke et al., 1998) |
| Exposure limits | TLV-TWA(skin) 8 mg/m3
(2 ppm) (ACGIH);
STEL (15 min) 19 mg/m3
(5 ppm) (NIOSH). |
| Dielectric constant | 22.9（20℃） |
| Stability: | Unstable. Flammable - note wide explosion limits and low flash point. |
| LogP | 0.45 at 20℃ |
Description and Uses
Epoxy resins of the bisphenol A type are synthesized from epichlorhydrin and bisphenol A. This leads to bisphenol-A diglycidyl ether, which is the monomer of bisphenol-A-based epoxy resins. Sensitization to epichlorhydrin occurs mainly in workers in the epoxy-resin industry. Sensitization in individuals not working at epoxy resin plants is rare. It has however been described to occur after contact with a soil fumigant, due to solvent cement and in a worker in a pharmaceutical plant, in a division for drug synthesis. Epichlorhydrin was used for the production of both drugs propranolol and oxprenolol.
Commercially the most important use is production of glycerine. Large volumes are consumed in nonglycerine areas, which largely consist of the various epoxy resins. It has use as a solvent and in the production of epichlorohydrin rubber.
Safety
| Symbol(GHS) |     GHS02,GHS05,GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H226-H301+H311+H331-H314-H317-H350 |
| Precautionary statements | P201-P210-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 |
| Hazard Codes | T |
| Risk Statements | 45-10-23/24/25-34-43 |
| Safety Statements | 53-45 |
| RIDADR | UN 2023 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | TX4900000 |
| Autoignition Temperature | 779 °F |
| TSCA | Yes |
| HS Code | 2910 30 00 |
| HazardClass | 6.1 |
| PackingGroup | II |
| Toxicity | LD50 orally in rats: 0.09 g/kg (Smyth, Carpenter) |
| IDLA | 75 ppm |
