Home Categories Organic Chemistry Ethyl cyanoacetate
A3952712

Ethyl cyanoacetate , StandardforGC,≥99.5%(GC) , 105-56-6

Synonym(s):
Cyanoacetic acid ethyl ester;Ethyl cyanoacetate

CAS NO.:105-56-6

Empirical Formula: C5H7NO2

Molecular Weight: 113.11

MDL number: MFCD00001940

EINECS: 203-309-0

Update time: 2022-07-08

PRODUCT Properties

Melting point: -22 °C (lit.)
Boiling point: 208-210 °C (lit.)
Density  1.063 g/mL at 25 °C (lit.)
vapor density  3.9 (vs air)
vapor pressure  1 mm Hg ( 67.8 °C)
refractive index  n20/D 1.418(lit.)
Flash point: >230 °F
storage temp.  Store below +30°C.
solubility  20g/l
form  Liquid
pka 3.19±0.10(Predicted)
color  Clear
Water Solubility  20 g/L (20 ºC)
Merck  14,3786
BRN  605871
Dielectric constant 26.9(20℃)
LogP -0.119-1.05 at 23-25℃ and pH6.1
Surface tension 70.2mN/m at 1.034g/L and 23℃
CAS DataBase Reference 105-56-6(CAS DataBase Reference)
NIST Chemistry Reference Acetic acid, cyano-, ethyl ester(105-56-6)
EPA Substance Registry System Ethyl cyanoacetate (105-56-6)

Description and Uses

Ethyl cyanoacetate is the ethyl ester of cyanoacetic acid. Ethyl cyanoacetate hydrolizes rapidly under neutral and alkaline conditions to cyanoacetic acid and ethanol (and so it does under most physiological and environmental conditions), while in acid pH the half life is considerably longer.
Knoevenagel condensation of ethyl cyanoacetate with aldehyde is reported. Microwave enhanced Knoevenegal condensation reaction of ethyl cyanoacetate with an aldehyde, P2O5, piperidine and chlorobenzene is reported.

Ethyl cyanoacetate may be used in the synthesis of ethyl glyoxylate. It was used to investigate the Knoevenagel condensation reactions in microreactor using zeolite catalysts obtained by grafting amino groups onto NaX and CsNaX zeolites.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H319
Precautionary statements  P264-P280-P305+P351+P338-P337+P313
Hazard Codes  Xn,Xi
Risk Statements  20/21/22-36/38
Safety Statements  36/37-37/39-26
RIDADR  3276
WGK Germany  1
RTECS  AG4110000
10
Autoignition Temperature 460 °C
TSCA  Yes
HS Code  2926 90 70
Hazardous Substances Data 105-56-6(Hazardous Substances Data)
Toxicity LD50 orally in Rabbit: > 2000 mg/kg

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