Ethyl cyanoacetate , 99% , 105-56-6
Synonym(s):
Cyanoacetic acid ethyl ester;Ethyl cyanoacetate
CAS NO.：105-56-6
Empirical Formula: C5H7NO2
Molecular Weight: 113.11
MDL number: MFCD00001940
EINECS: 203-309-0
PRODUCT Properties
| Melting point: | -22 °C (lit.) |
| Boiling point: | 208-210 °C (lit.) |
| Density | 1.063 g/mL at 25 °C (lit.) |
| vapor density | 3.9 (vs air) |
| vapor pressure | 1 mm Hg ( 67.8 °C) |
| refractive index | n |
| Flash point: | >230 °F |
| storage temp. | Store below +30°C. |
| solubility | 20g/l |
| form | Liquid |
| pka | 3.19±0.10(Predicted) |
| color | Clear |
| Water Solubility | 20 g/L (20 ºC) |
| Merck | 14,3786 |
| BRN | 605871 |
| Dielectric constant | 26.9（20℃） |
| LogP | -0.119-1.05 at 23-25℃ and pH6.1 |
| Surface tension | 70.2mN/m at 1.034g/L and 23℃ |
| CAS DataBase Reference | 105-56-6(CAS DataBase Reference) |
| NIST Chemistry Reference | Acetic acid, cyano-, ethyl ester(105-56-6) |
| EPA Substance Registry System | Ethyl cyanoacetate (105-56-6) |
Description and Uses
Ethyl cyanoacetate is the ethyl ester of cyanoacetic acid. Ethyl cyanoacetate hydrolizes rapidly under neutral and alkaline conditions to cyanoacetic acid and ethanol (and so it does under most physiological and environmental conditions), while in acid pH the half life is considerably longer.
Knoevenagel condensation of ethyl cyanoacetate with aldehyde is reported. Microwave enhanced Knoevenegal condensation reaction of ethyl cyanoacetate with an aldehyde, P2O5, piperidine and chlorobenzene is reported.
Ethyl cyanoacetate may be used in the synthesis of ethyl glyoxylate. It was used to investigate the Knoevenagel condensation reactions in microreactor using zeolite catalysts obtained by grafting amino groups onto NaX and CsNaX zeolites.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H319 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313 |
| Hazard Codes | Xn,Xi |
| Risk Statements | 20/21/22-36/38 |
| Safety Statements | 36/37-37/39-26 |
| RIDADR | 3276 |
| WGK Germany | 1 |
| RTECS | AG4110000 |
| F | 10 |
| Autoignition Temperature | 460 °C |
| TSCA | Yes |
| HS Code | 2926 90 70 |
| Hazardous Substances Data | 105-56-6(Hazardous Substances Data) |
| Toxicity | LD50 orally in Rabbit: > 2000 mg/kg |
