PRODUCT Properties
Melting point: | 167-172°C |
Boiling point: | bp2.0 150-165° |
Density | 0.9889 (rough estimate) |
refractive index | 1.5450 to 1.5490 |
storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
solubility | Chloroform (Slightly), Methanol (Slightly) |
form | Oil |
pka | pKa 9.1 (Uncertain) |
color | Oil |
Merck | 14,3309 |
BCS Class | 1 |
Description and Uses
Diphenhydramine is one of the main representatives of antihistamine drugs that block H1 receptors. Besides antihistamine activity, diphenhydramine exhibits a local anesthetic effect, relaxes smooth muscle, and has sedative and soporific action.
Antihistaminic.
Safety
Symbol(GHS) | GHS07 |
Signal word | Warning |
Hazard statements | H319-H315-H302 |
Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501 |
RTECS | KR6825000 |
HS Code | 2922.19.7000 |
Toxicity | LD50 oral in rat: 390mg/kg |