Desloratadine , >98.0%(HPLC)(T) , 100643-71-8

Synonym(s):
8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H- benzo[5,6]cyclohepta[1,2,b]pyridine;Clarinex;Desloratadine;NSC 675447

CAS NO.：100643-71-8

Empirical Formula: C19H19ClN2

Molecular Weight: 310.82

MDL number: MFCD00871949

EINECS: 638-878-8

PRODUCT Properties

• Melting point: 150-151°C
• Boiling point: 467.9±45.0 °C(Predicted)
• Density: 1?+-.0.06 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMSO: >10mg/mL
• pka: 10.27±0.20(Predicted)
• form: powder
• color: White to Light orange to Yellow
• Merck: 14,2922
• BCS Class: 1
• InChIKey: JAUOIFJMECXRGI-UHFFFAOYSA-N
• CAS DataBase Reference: 100643-71-8(CAS DataBase Reference)

Description and Uses

Desloratadine is a second generation of tricyclic antihistamine. It is a H1-receptor antagonist which has anti-inflammatory activity. Its affinity to the H1 receptor is higher than most other H1-receptor antagonists. Desloratadine works by blocking a certain natural substance (histamine) which is produced during an allergic reaction. Desloratidine has a long-lasting effect and does not cause drowsiness because it does not readily enter the central nervous system.
Desloratadine is used to treat nasal and non-nasal symptoms (watery eyes, runny nose, itching eyes/nose, sneezing, and itching) of seasonal allergic rhinitis. It is also used to relieve chronic itching caused by hives.

For the relief of symptoms of seasonal allergic rhinitis, perennial (non-seasonal) allergic rhinitis. Desloratidine is also used for the sympomatic treatment of pruritus and urticaria (hives) associated with chronic idiopathic urticaria.

Safety

• Symbol(GHS): GHS08,GHS07,GHS05,GHS09
• Signal word: Danger
• Hazard statements: H361-H302-H318-H411
• Precautionary statements: P264-P270-P301+P312-P330-P501-P280-P305+P351+P338-P310-P201-P202-P281-P308+P313-P405-P501
• WGK Germany: 3
• RTECS: DE8011000
• HS Code: 2933399090