2,4-Diamino-6-hydroxypyrimidine , >98.0%(HPLC) , 56-06-4

CAS NO.：56-06-4

Empirical Formula: C4H6N4O

Molecular Weight: 126.12

MDL number: MFCD00006098

EINECS: 200-254-4

PRODUCT Properties

• Melting point: 285-286 °C (dec.) (lit.)
• Boiling point: 234.22°C (rough estimate)
• Density: 1.3659 (rough estimate)
• refractive index: 1.7990 (estimate)
• storage temp.: Keep in dark place,Inert atmosphere,Room temperature
• solubility: DMSO (Slightly), Methanol (Slightly)
• pka: 10.61±0.50(Predicted)
• form: Fine Crystalline Powder
• color: White to cream
• Sensitive: Light Sensitive
• Merck: 14,2981
• BRN: 125006
• InChIKey: SWELIMKTDYHAOY-UHFFFAOYSA-N
• CAS DataBase Reference: 56-06-4(CAS DataBase Reference)
• NIST Chemistry Reference: 4(1H)-pyrimidinone, 2,6-diamino-(56-06-4)
• EPA Substance Registry System: 2,6-Diamino-4(1H)-pyrimidinone (56-06-4)

Description and Uses

2,4-Diamino-6-hydroxypyrimidine (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis. In HUVEC cells, the IC₅₀ for inhibition of BH₄ biosynthesis is about 0.3 mM. DAHP can be used to effectively block NO production in several cell types.

2,4-Diamino-6-hydroxypyrimidine (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis. In HUVEC cells, the IC50 for inhibition of BH4 biosynthesis is about 0.3 mM. DAHP can be used to effectively block NO production in several cell types.[Cayman Chemical]

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319
• Precautionary statements: P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 22-24/25-36-26
• WGK Germany: 3
• Hazard Note: Irritant
• TSCA: Yes
• HS Code: 29335995