1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane , ≥97% , 69304-37-6

Synonym(s):
TIPDSiCl₂

CAS NO.：69304-37-6

Empirical Formula: C12H28Cl2OSi2

Molecular Weight: 315.43

MDL number: MFCD00009655

EINECS: 629-558-9

PRODUCT Properties

• Boiling point: 70 °C0.5 mm Hg(lit.)
• Density: 0.986 g/mL at 25 °C(lit.)
• refractive index: n20/D 1.454(lit.)
• Flash point: >230 °F
• storage temp.: Inert atmosphere,2-8°C
• solubility: Miscible with dimethylformamide, hexane, ethyl acetate, chloroform and dichloromethane.
• form: Oil
• color: Colourless
• Specific Gravity: 0.986
• Hydrolytic Sensitivity: 8: reacts rapidly with moisture, water, protic solvents
• Sensitive: Moisture Sensitive
• BRN: 1934216
• InChI: InChI=1S/C12H28Cl2OSi2/c1-9(2)16(13,10(3)4)15-17(14,11(5)6)12(7)8/h9-12H,1-8H3
• InChIKey: DDYAZDRFUVZBMM-UHFFFAOYSA-N
• SMILES: [Si](Cl)(C(C)C)(C(C)C)O[Si](Cl)(C(C)C)C(C)C

Description and Uses

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane can be used as simultaneous protection of the 3'- and 5'-hydroxyl functions of furanose nucleosides;protecting group for carbohydrates;3,4 protecting group reagent for open-chain polyhydroxy compounds; preparation of cyclic bridged peptides.
The reagent design was based upon the fact that triisopropylsilyl chloride reacts 1000 times faster with primary alcohols than secondary alcohols. Thus in the case of 3',5'-dihydroxy nucleosides the reagent initially silylates at the 5'-position. This is then followed by intramolecular reaction with the secondary alcohol at the 3'-position to give the doubly protected derivative (eq 1).

Safety

• Symbol(GHS): GHS05
• Signal word: Danger
• Hazard statements: H290-H314
• Precautionary statements: P280-P303+P361+P353-P305+P351+P338+P310
• Hazard Codes: C
• Risk Statements: 34
• Safety Statements: 26-27-28-36/37/39-45
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 3
• F: 10-21
• Hazard Note: Corrosive
• TSCA: No
• HazardClass: 8
• PackingGroup: II
• HS Code: 29319090