22,23-Dihydroergocalciferol , ≥97.0%(HPLC) , 511-28-4

Synonym(s):
Cholecalciferol;Calciol;Vitamin D₄;(+)-Vitamin D₃;(3β,5Z,7E)-9,10-Secoergosta-5,7,10(19)-trien-3-ol

CAS NO.：511-28-4

Empirical Formula: C28H46O

Molecular Weight: 398.66

MDL number: MFCD00078131

EINECS: 208-127-5

PRODUCT Properties

• Melting point: 83-86 °C(lit.)
• alpha: D18 +89.3° (c = 0.47 in acetone)
• Boiling point: 504.9±29.0 °C(Predicted)
• Density: 0.96
• storage temp.: 2-8°C
• solubility: Soluble in Chloroform
• form: Powder
• pka: 14.74±0.20(Predicted)
• color: Off-white to light yellow
• Stability: Hygroscopic, Temperature Sensitive

Description and Uses

Derived from cholesterol, vitamin D is biosynthesized from its prohormone cholecalciferol (D3), the product of solar ultraviolet irradiation of 7-dehydrocholesterol in the skin. In 1966, it was first recognized that vitamin D must undergo activation via two oxidative metabolic steps. The first oxidation to 25-hydroxycholecalciferol (25(OH)D3: calcifediol; Calderol) occurs in the endoplasmic reticulum of the liver and is catalyzed by vitamin D 25-hydroxylase. This activation step is not regulated by plasma calcium concentrations. The major circulating form (10–80 μg/mL) is 25(OH)D3, which also is the primary storage form of vitamin D.

Vitamin D4 is the active analogue of Vitamin D.

Safety

• Symbol(GHS): GHS06,GHS08
• Signal word: Danger
• Hazard statements: H301+H311-H330-H372
• Precautionary statements: P280-P301+P310+P330-P302+P352+P312-P304+P340+P310-P314
• Hazard Codes: T+
• Risk Statements: 24/25-26-48/25
• Safety Statements: 28-36/37
• RIDADR: UN 2811 6.1/PG 2
• WGK Germany: 2
• RTECS: VS2900000
• F: 8-10-23