Home Categories Biochemical Engineering 7,8-Dihydroxyflavone Hydrate
A3401112

7,8-Dihydroxyflavone Hydrate , ≥98.0%(HPLC) , 38183-03-8

CAS NO.:38183-03-8

Empirical Formula: C15H10O4

Molecular Weight: 254.24

MDL number: MFCD00006836

EINECS: 253-812-4

Pack Size Price Stock Quantity
1G RMB204.00 In Stock
5G RMB612.80 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 243-246°C
Boiling point: 494.4±45.0 °C(Predicted)
Density  1.443±0.06 g/cm3(Predicted)
FEMA  4830 | 7,8-DIHYDROXYFLAVONE
storage temp.  Inert atmosphere,Room Temperature
solubility  DMSO: soluble24mg/mL
form  solid
pka 6.86±0.40(Predicted)
color  Yellow or tan
Stability: Stable for 1 year from date of purchase as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 week.
InChI InChI=1S/C15H10O4/c16-11-7-6-10-12(17)8-13(19-15(10)14(11)18)9-4-2-1-3-5-9/h1-8,16,18H
InChIKey COCYGNDCWFKTMF-UHFFFAOYSA-N
SMILES C1(C2=CC=CC=C2)OC2=C(O)C(O)=CC=C2C(=O)C=1
LogP 2.760 (est)

Description and Uses

7,8-Dihydroxyflavone(7,8-DHF) is a naturally occurring flavone found in the tree Godmania aesculifolia. It is a selective tyrosine kinase receptor B(TrkB) agonist that has neurotrophic effects in various neurological diseases such as stroke and Parkinson's disease. 7,8-Dihydroxyflavone binds to the TrkB receptors in a similar way to BDNF, or brain derived neurotrophic factor. When the TrkB receptor is activated, neuroprotective and neurogenetive effects occur in neurons, which tend to affect the dendrites. Dendrites are what reach out from the neurons into the synapse to participate in signaling with other neurons. 7,8-DHF has been shown to promote the growth of these dendrites, and to help restore communication between neurons in animal models.

7,8-Dihydroxyflavone is disubstituted flavone that acts as a small-molecule TrkB agonist. 7,8-Dihydroxyflavone has been shown to reverse memory deficits and BACE1 elevation in a mouse model of Alzheimer''s disease. 7,8-Dihydroxyflavone may also provide a therapeutic option in the treatment of other neorological disorders such as Rett syndrome and PTSD. It has recently been shown to counteract the inhibition of NMDA receptor caused by lead poisoning and confer protective effects in live rats.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22
Safety Statements  24/25
WGK Germany  3
RTECS  DJ3004000
HS Code  2932990090

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