4-Deoxypyridoxine Hydrochloride , ≥98.0%(HPLC) , 148-51-6

CAS NO.：148-51-6

Empirical Formula: C8H12ClNO2

Molecular Weight: 189.64

MDL number: MFCD00051296

EINECS: 205-714-8

PRODUCT Properties

• Melting point: 274°C(dec.)(lit.)
• storage temp.: Inert atmosphere,Room Temperature
• solubility: DMSO (Slightly, Heated), Methanol (Slightly, Heated)
• form: Solid
• color: White to Pale Red
• Stability: Hygroscopic

Description and Uses

4-deoxy Pyridoxine (DOP) is a vitamin B₆ antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in and reduces growth of S. carlsbergensis cells. DOP inhibits sphingosine-1-phosphate (S1P) lyase and reduces cyclic stretch-induced apoptosis in alveolar epithelial MLE-12 cells. DOP (5 mg, i.p.) reduces lysyl oxidase activity by 26% and reduces collagen and elastin crosslinking, resulting in limb abnormalities in chick embryos. It decreases latency to first seizure in mice (ED₅₀ = 1 mmol/kg) and increases the occurrence and duration of myoclonic responses in baboons with photosensitive epilepsy. DOP reduces TNF-α and IL-6 production in mice infected with T. spiralis.

4-Deoxypyridoxine is the deoxy analogue of Pyridoxine (P991735). 4-Deoxypyridoxine is a vitamin B6 antimetabolite; 4-Deoxypyridoxine can induce a deficient status that alters the function and ultrastructure of EC similar to vascular disease.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P280-P301+P312-P302+P352-P305+P351+P338
• WGK Germany: 3
• RTECS: UT4800000
• HS Code: 29333990
• Toxicity: LD50 oral in chicken: 1570mg/kg