Diisopropylamine dichloroacetate , 95% , 660-27-5

CAS NO.：660-27-5

Empirical Formula: C8H17Cl2NO2

Molecular Weight: 230.132

MDL number: MFCD00868288

EINECS: 211-538-2

PRODUCT Properties

• Melting point: 119-121°
• RTECS: AG6475000
• storage temp.: Sealed in dry,Room Temperature
• solubility: DMSO (Slightly), Methanol (Slightly)
• form: Crystalline Powder
• color: White
• Merck: 14,3197
• Stability: Hygroscopic
• InChI: InChI=1S/C6H15N.C2H2Cl2O2/c1-5(2)7-6(3)4;3-1(4)2(5)6/h5-7H,1-4H3;1H,(H,5,6)
• InChIKey: ILKBHIBYKSHTKQ-UHFFFAOYSA-N
• SMILES: C(O)(=O)C(Cl)Cl.CC(NC(C)C)C

Description and Uses

Diisopropylammonium dichloroacetate is a hepatoprotective drug that improves the energy metabolism of hepatocytes, promotes the regeneration of injured hepatocytes, increases the rate of tissue cell respiration and oxygen respiration, and reduces the accumulation of fat in the liver. It is mainly used clinically for the treatment of fatty liver, intrahepatic cholestasis, and general liver dysfunction. It is also used in the treatment of acute and chronic hepatitis, hepatomegaly, and early cirrhosis.

Diisopropylammonium dichloroacetate (DIPA) is known to produce a significant and prolonged hypoglycemic effect in alloxan-diabetic but not in normal rats.
Diisopropylamine 2,2-Dichloroacetate is used in the treatment of antituberculosis drugs-induced liver injury.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P264-P270-P280-P301+P312+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P501-P261-P280a-P304+P340-P305+P351+P338-P405-P501a
• TSCA: Yes
• HS Code: 2921199990
• Toxicity: LD50 orally in mice: 1700 mg/kg (Kraushaar)