Home Categories Natural Products Geraniin
A3372057

Geraniin , 98% , 60976-49-0

CAS NO.:60976-49-0

Empirical Formula: C41H28O27

Molecular Weight: 952.64

MDL number: MFCD09038731

Pack Size Price Stock Quantity
5mg RMB255.20 In Stock
10mg RMB431.20 In Stock
25mg RMB911.20 In Stock
50mg RMB1551.20 In Stock
100mg RMB2639.20 In Stock
others     Enquire
Update time: 2022-07-08

PRODUCT Properties

Density  2.25
storage temp.  under inert gas (nitrogen or Argon) at 2–8 °C
solubility  DMSO : 100 mg/mL (104.97 mM; Need ultrasonic)
form  powder
pka 6.35±0.70(Predicted)
color  Light yellow

Description and Uses

Geraniin is a tannin that has been found in P. urinaria and has diverse biological activities. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; IC50s = 0.92 and 1.27 μM at pH 4.5 and 7.9, respectively), superoxide (IC50 = 2.65 μM), and hydroxyl radicals (IC50 = 1.44 μM) in cell-free assays. Geraniin inhibits herpes simplex virus 1 (HSV-1) and HSV-2 replication in plaque reduction assays (IC50s = 35 and 18.4 μM, respectively). It inhibits angiotensin-converting enzyme (ACE) in vitro (IC50 = 13.22 μM) and reduces both systolic and diastolic blood pressure in spontaneously hypertensive rats when administered at a dose of 5 mg/kg. Geraniin (5, 10, and 20 μM) induces apoptosis and halts the cell cycle at the S phase in A549 lung cancer cells. It reduces tumor growth in an A549 mouse xenograft model when administered at doses of 10 and 20 mg/kg.

Geraniin protects PC12 cells against neuronal damage and may be used in the treatment of Alzheimer’s disease/ Also is an ACE inhibitor which is useful for hypertension treatment.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338

RELATED PRODUCTS