Dansylcadaverine [N-(5-Aminopentyl)-5-dimethylaminonaphthalen-1-sulfonamide] , ≥99.0%(HPLC), used for fluorescence analysis , 10121-91-2

Synonym(s):
N-(5-Amino-pentyl)-5-di-methyl-amino-naphtha-lene-1-sulfon-amide;N-(Dimethyl-amino-naphtha-lene-sulfonyl)-1,5-pentane-diamine;Monodansyl cadaverine

CAS NO.：10121-91-2

Empirical Formula: C17H25N3O2S

Molecular Weight: 335.46

MDL number: MFCD00042704

EINECS: 233-326-9

PRODUCT Properties

• Melting point: 137-140 °C
• Boiling point: 505.5±60.0 °C(Predicted)
• Density: 1.190±0.06 g/cm3(Predicted)
• storage temp.: −20°C
• pka: 11.96±0.50(Predicted)
• form: powder
• color: Yellow to yellowish green
• λmax: 335 nm
• BRN: 2951070
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or methanol may be stored at -20°C for up to 1 month.
• Biological Applications: Measuring cardiac autophagic flux; treating cataract,fibrosis,Parkinson’s disease,peritoneal ovarian tumor dissemination,respiratory diseases,lung diseases,Huntington’s disease,spinobulbar atrophy,spinocerebellar ataxia,denta

Description and Uses

Monodansylcadaverine (MDC) is a fluorescent marker for autophagic vacuoles. It is an autofluorescent substance incorporated into multilamellar bodies by both an ion trapping mechanism and interaction with membrane lipids, exhibiting a Stokes shift and increased relative fluorescence in hydrophobic environments. MDC selectively accumulates in PaTu 8902 subcellular fractions containing the lysosomal enzymes acid phosphatase and cathepsin D, but not those containing the rough and smooth endoplasmic reticulum markers TRAM and cytochrome P450, respectively.

Lysosomotropic fluorescent Probe

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 10-23