Dienogest , ≥99% , 65928-58-7

Synonym(s):
(17a)-17-Hydroxy-3-oxo-19-norpregna-4,9-diene-21-nitrile;17-cyanomethyl-17-hydroxy-estra-4,9-dien-3-one;17-Hydroxy-3-oxo-19-norpregna-4,9-diene-21-nitrile

CAS NO.：65928-58-7

Empirical Formula: C20H25NO2

Molecular Weight: 311.43

MDL number: MFCD00868356

EINECS: 639-448-2

PRODUCT Properties

• Melting point: 210-2140C
• alpha: D25 -290° (c = 0.5 in pyridine)
• Boiling point: 451.46°C (rough estimate)
• Density: 1.0899 (rough estimate)
• refractive index: 1.5614 (estimate)
• storage temp.: 2-8°C
• solubility: Chloroform (Slightly), Pyridine (Slightly)
• form: powder
• pka: 13?+-.0.40(Predicted)
• color: white to beige
• optical activity: [α]/D -305 to -325°, c = 1 in dichloromethane
• Merck: 14,3106
• InChI: InChI=1/C20H25NO2/c1-19-8-6-16-15-5-3-14(22)12-13(15)2-4-17(16)18(19)7-9-20(19,23)10-11-21/h12,17-18,23H,2-10H2,1H3/t17-,18+,19+,20-/s3
• InChIKey: AZFLJNIPTRTECV-XAYGXGNENA-N
• SMILES: C[C@]12CCC3=C4CCC(=O)C=C4CC[C@@]3([H])[C@]1([H])CC[C@@]2(O)CC#N |&1:1,14,16,20,r|

Description and Uses

Dienogest is an orally active synthetic progesterone (or progestin). It is available for use as an oral contraceptive in combination with ethinylestradiol. It has antiandrogenic activity and as a result can improve androgenic symptoms.

Safety

• Symbol(GHS): GHS08
• Signal word: Warning
• Hazard statements: H361
• Precautionary statements: P280
• RTECS: RC8899500
• HS Code: 2937.23.5050
• Toxicity: LD50 oral in mouse: 4gm/kg