Diclofenac Sodium , ≥99% , 15307-79-6

Synonym(s):
2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid sodium salt;2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid, Na;Diclofenac Sodium - CAS 15307-79-6 - Calbiochem;Diclofenac sodium salt

CAS NO.：15307-79-6

Empirical Formula: C14H10Cl2NNaO2

Molecular Weight: 318.13

MDL number: MFCD00082251

EINECS: 239-346-4

PRODUCT Properties

• Melting point: 288-290°C
• Density: 0.781 g/cm3
• storage temp.: room temp
• solubility: H₂O: 50 mg/mL
• pka: 4(at 25℃)
• form: White solid
• color: White to Almost white
• Water Solubility: Soluble in water to 50mg/ml.
• Merck: 14,3081
• BCS Class: 2
• Stability: Stable.
• InChI: InChI=1S/C14H11Cl2NO2.Na/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1
• InChIKey: KPHWPUGNDIVLNH-UHFFFAOYSA-M
• SMILES: C1(=CC=CC=C1CC([O-])=O)NC1=C(Cl)C=CC=C1Cl.[Na+]

Description and Uses

Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC₅₀s = 0.9-2.7 and 1.5-20 μM, for human COX-1 and COX-2, respectively). It is also an active metabolite of diclofenac methyl ester and diclofenac amide . Diclofenac inhibits release of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) induced by A23187 in isolated rat peritoneal neutrophils and macrophages (IC₅₀s = 60 and 10 μM, respectively). Transdermal administration of diclofenac inhibits carrageenan-induced paw edema in rats. Formulations containing diclofenac have been used in the treatment of pain associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.

Diclofenac sodium is a nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor. Oxidation of diclofenac sodium produces the metabolite 4'-hydroxy diclofenac) which demonstrates specific inhibition of Cox-2. Inhibition of Cox by diclofenac and 4'-hydroxy diclofenac suppresses prostaglandin E2 synthesis, producing anti-inflammatory and analgesic effects. Diclofenac is also shown to stabilize the native tetrameric conformation of transthyretin (TTR) fibrils, preventing the formation of insoluble amyloidogenic TTR deposits. Diclofenac Sodium is a substrate of CYP2C9. It is also used as an inhibitor of Cox-1 and Cox-2.

Safety

• Symbol(GHS): GHS06,GHS08,GHS09
• Signal word: Danger
• Hazard statements: H301-H361d-H372-H411
• Precautionary statements: P201-P202-P260-P264-P273-P301+P310
• Hazard Codes: T,Xi
• Risk Statements: 25-36/37/38-63
• Safety Statements: 22-36/37-45-36-26-60-20
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: AG6330000
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 29224999
• Toxicity: LD50 in mice, rats (mg/kg): ~390, 150 orally (Krupp)