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A3316212

Doramectin , 98% , 117704-25-3

Synonym(s):
25-Cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)avermectin;Doramectin

CAS NO.:117704-25-3

Empirical Formula: C50H74O14

Molecular Weight: 899.11

MDL number: MFCD00894747

EINECS: 601-490-4

Pack Size Price Stock Quantity
1G RMB347.20 In Stock
5G RMB1092.00 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 116-1190C
Boiling point: 967.4±65.0 °C(Predicted)
Density  1.25±0.1 g/cm3(Predicted)
vapor pressure  0Pa at 20℃
storage temp.  Sealed in dry,Store in freezer, under -20°C
solubility  methanol: soluble
form  solid
pka 12.42±0.70(Predicted)
color  white
InChIKey QLFZZSKTJWDQOS-YDBLARSUSA-N
LogP 4.39-4.43 at 25℃

Description and Uses

Doramectin[117704-25-3] is a novel avermectin with a cyclohexyl substituent on the previously inaccessible C-25 position of the molecule; the substitution was facilitated by mutational biosynthesis. The discovery of doramectin involved feeding carboxylic acids or their precursors to a fermentation of Streptomyces avermitilis that lacked branched-chain 2-oxo acid dehydrogenase activity, and then screening the resultant fermentation products for anthelmintic and ectoparasiticidal activity. Two dosage forms of doramectin have been developed for use as an endectocide on cattle, an injectable formulation for subcutaneous administration and a pouron formulation. An injectable formulation is also approved for use on pigs.

Doramectin is a biosynthetic avermectin derived from a mutant strain of Streptomyces avermitilis, supplemented with a cyclohexylcaboxylic acid starting unit. Doramectin was developed as an anthelmintic for internal parasite control. The presence of the cyclohexyl group replacing the sec-butyl moiety affords greater hydrophobicity and longer biological half-life compared to avermectin. Like the other milbemycin/avermectins, it selectively binds to parasite glutamate-gated chloride ion channels and disrupts neurotransmission leading to paralysis and death of the parasite.

Safety

Symbol(GHS) 
GHS07,GHS08,GHS09
Signal word  Warning
Hazard statements  H302-H361fd-H362-H410
Precautionary statements  P202-P260-P263-P273-P301+P312-P308+P313
Hazard Codes  T,N,Xi
Risk Statements  25-50/53-36/37/38
Safety Statements  33-45-60-61-36/37-26
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
HS Code  29419090

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