D609 , ≥98% , 83373-60-8
Synonym(s):
D609;D609, Potassium Salt - CAS 83373-60-8 - Calbiochem;Tricyclodecan-9-yl-xanthogenate, K
CAS NO.：83373-60-8
Empirical Formula: C11H15KOS2
Molecular Weight: 266.46
MDL number: MFCD00171401
EINECS: 280-379-9
| Pack Size | Price | Stock | Quantity |
| 5MG | RMB356.00 | In Stock |
|
| 10MG | RMB570.40 | In Stock |
|
| 50MG | RMB2082.40 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| storage temp. | 0-6°C |
| solubility | H2O: 300 mg/mL |
| form | solid |
| color | off-white |
| Water Solubility | Soluble to 100 mM in water |
Description and Uses
D609 is a xanthate and a competitive inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC; Ki = 6.4 μM). It has no effect on bacterial phosphatidylinositol-specific PLC, bovine pancreatic PLA2, or phospholipase D. D609 reduces sphingomyelin synthase activity by 55.5 and 90.5% in membrane preparations when used at concentrations of 100 and 200 mg/ml, respectively. Similar to other xanthates, D609 has antioxidant, antiviral, and anti-tumor activities. In addition, it has anti-inflammatory actions, inhibiting LPS-stimulated expression of nitric oxide synthase (NOS) in phagocytes (IC50 = 20 μg/ml) and IL-1β-induced expression of vascular cell adhesion molecule 1 (VCAM-1) in endothelial cells.
D609 has been used as a phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor in mouse bone marrow derived monocytes. D609 has also been reported to significantly reduce the elevated levels of phosphatidylethanolamine binding protein 1 (PEBP1) in apolipoprotein E-/- mice.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501 |
| Risk Statements | 22 |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| HS Code | 29333990 |
