DAPT , ≥98% , 208255-80-5

Synonym(s):
γ-Secretase Inhibitor IX - CAS 208255-80-5 - Calbiochem;DAPT, N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester

CAS NO.：208255-80-5

Empirical Formula: C23H26F2N2O4

Molecular Weight: 432.46

MDL number: MFCD04974585

PRODUCT Properties

• alpha: +40.0～+47.0°(D/20℃)(c=0.5,DMSO)
• Boiling point: 612.2±55.0 °C(Predicted)
• Density: 1.213
• storage temp.: 2-8°C
• solubility: DMSO: ~18 mg/mL
• form: solid
• pka: 12.82±0.46(Predicted)
• color: white
• Sensitive: Light Sensitive
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
• InChIKey: DWJXYEABWRJFSP-XOBRGWDASA-N
• CAS DataBase Reference: 208255-80-5

Description and Uses

DAPT (208255-80-5) is an inhibitor of γ-secretase (IC50 in human primary neurons = 115 nM for total Aβ or 200 nM for Aβ42 specifically).1?Oral administration of DAPT has been shown to reduce levels of Aβ in brain extract, cerebrospinal fluid and plasma from mice and rats.2,3?DAPT blocks Notch signaling which promotes neuronal differentiation of precursor cells.4?Enhances iPS cells without oncogenes KLF4 and CMYC5. Cell permeable.

A potent and specific inhibitor of γ-secretase.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319
• Precautionary statements: P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330
• Safety Statements: 24/25
• WGK Germany: 3
• HS Code: 29242990