2,3-Dichloroquinoxaline , 98% , 2213-63-0

CAS NO.：2213-63-0

Empirical Formula: C8H4Cl2N2

Molecular Weight: 199.04

MDL number: MFCD00006720

EINECS: 218-667-3

PRODUCT Properties

• Melting point: 152-154 °C (lit.)
• Boiling point: 325.69°C (rough estimate)
• Density: 1.4994 (rough estimate)
• refractive index: 1.6400 (estimate)
• storage temp.: Keep in dark place,Sealed in dry,Room Temperature
• Water Solubility: Insoluble in water
• solubility: soluble in Chloroform
• pka: -4.78±0.48(Predicted)
• form: Needles
• color: Off-white to light brown
• BRN: 126076
• Stability: Stable. Incompatible with strong oxidizing agents.
• InChIKey: SPSSDDOTEZKOOV-UHFFFAOYSA-N

Description and Uses

2,3-Dichloroquinoxaline (DCQX) can be used as a substrate for nucleophilic aromatic substitution (SNAr) reactions and is a versatile building block for the synthesis of many quinoxaline derivatives. 2,3-Dichloroquinoxaline reacts with 6-aminothiouracil in ethanol/TEA to form 6-amino-2-(3-chloroquinoxalin-2-ylthio)pyrimidin-4(3H)-one. It reacts with cholest-5-en-3-one semicarbazone/thiosemicarbazone to form steriodal cholest-5-en-3-oxazolo and thiazoloquinoxaline.

2,3-Dichloroquinoxaline was used in the synthesis of mono and 2,3-disubstituted quinoxalines. It was used in solid phase synthesis of HPLC chiral stationary phase containing the N,N′-dialkyl-2,3-diaminoquinoxaline group as a linking structure.

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H301-H315-H319-H335
• Precautionary statements: P301+P310+P330-P302+P352-P305+P351+P338
• Hazard Codes: T
• Risk Statements: 25-36/37/38
• Safety Statements: 26-36/37/39-45-37/39-28A
• RIDADR: 2811
• WGK Germany: 3
• RTECS: VD1720000
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: III
• HS Code: 29339900
• Toxicity: mouse,LD50,intravenous,5600ug/kg (5.6mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#03256,