A3214512
Domiphen bromide , 97% , 538-71-6
Synonym(s):
(Dodecyldimethyl-2-phenoxyethyl)ammonium bromide
CAS NO.：538-71-6
Empirical Formula: C22H40BrNO
Molecular Weight: 414.46
MDL number: MFCD00011769
EINECS: 208-702-0
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 117-119 °C (lit.) |
| Density | 1.1411 (rough estimate) |
| refractive index | 1.5570 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | White to Off-White |
| Water Solubility | Soluble in ethanol, acetone, ethyl acetate, chloroform and water. Slightly soluble in benzene. |
| Sensitive | Hygroscopic |
| Merck | 14,3415 |
| BRN | 3922742 |
| InChIKey | OJIYIVCMRYCWSE-UHFFFAOYSA-M |
| CAS DataBase Reference | 538-71-6(CAS DataBase Reference) |
| EPA Substance Registry System | 1-Dodecanaminium, N,N-dimethyl-N-(2-phenoxyethyl)-, bromide (1:1) (538-71-6) |
Description and Uses
Domiphen is a quaternary ammonium compound and cationic surfactant with antimicrobial activity. It is active against A. viscosus, A. naeslundii, S. mutans, E. coli, and L. monocytogenes bacteria and inhibits C. neoformans yeast growth and spore germination. It also inhibits the human-ether-a-go-go-related gene (hERG) channel (IC50 = 1.5 μM in a whole-cell patch-clamp assay). Formulations containing domiphen have been used as antiseptics, disinfectants, and biocides in industrial, agricultural, veterinary, and clinical applications.
Antiinfective, topical.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | BQ2030000 |
| TSCA | Yes |
| HazardClass | 6.1 |
| PackingGroup | III |
| Hazardous Substances Data | 538-71-6(Hazardous Substances Data) |
