Home Categories Pharmaceutical intermediates 2,3-Dichloro-5,6-dicyano-p-benzoquinone
A3192012

2,3-Dichloro-5,6-dicyano-p-benzoquinone , 98% , 84-58-2

Synonym(s):
4,5-Dichloro-3,6-dioxo-1,4-cyclohexadiene-1,2-dicarbonitrile;DDQ

CAS NO.:84-58-2

Empirical Formula: C8Cl2N2O2

Molecular Weight: 227

MDL number: MFCD00001593

EINECS: 201-542-2

Update time: 2022-07-08

PRODUCT Properties

Melting point: 210-215 °C (dec.)(lit.)
Boiling point: 301.8±42.0 °C(Predicted)
Density  1.7500 (estimate)
storage temp.  Store below +30°C.
solubility  Soluble in benzene, methanol, acetic acid and dioxane.Slightly soluble in chloroform,, dichloromethane.
form  Crystalline Powder or Crystals
color  Yellow to orange
Water Solubility  reacts
Sensitive  Moisture Sensitive
Merck  14,3063
BRN  747939
InChIKey HZNVUJQVZSTENZ-UHFFFAOYSA-N
CAS DataBase Reference 84-58-2(CAS DataBase Reference)
NIST Chemistry Reference 1,4-Cyclohexadiene-1,2-dicarbonitrile, 4,5-dichloro-3,6-dioxo-(84-58-2)
EPA Substance Registry System 1,4-Cyclohexadiene-1,2-dicarbonitrile, 4,5-dichloro-3,6-dioxo- (84-58-2)

Description and Uses

2,3-Dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) has a variety of applications. DDQ is a deprotection agent for ketals, acetals, and thioacetals. It is a useful electron transfer reagent for synthesis of quinolones and an oxidizing agent used to synthesize steroids. Additionally, DDQ is used with Ph3P to synthesize 1,2-benzisoxazoles.

An oxidizing agent, especially in steroid synthesis.
2,3-Dichloro-5,6-dicyano-1,4-benzoquinone is used as a reagent for oxidative couplings and cyclization reactions and dehydrogenation of alcohols, phenols and steroid ketones. It is also used in the synthesis of 1,2-benzisoxazoles. It is a useful electron-transfer reagent for synthesis of quinolines from imines and alkynes or alkenes.

Safety

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P264-P270-P301+P310-P405-P501
Hazard Codes  T
Risk Statements  25-29-41-37/38-20/21-23/24/25
Safety Statements  22-24/25-37-45-36/37-26-36/37/39
RIDADR  UN 3439 6.1/PG 3
WGK Germany  3
RTECS  GU4825000
21
TSCA  Yes
HazardClass  6.1
PackingGroup  II
HS Code  29269095

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