Di-tert-butyl dicarbonate , 98% , 24424-99-5

Synonym(s):
Boc anhydride;Boc₂O;Di-tert-butyl pyrocarbonate;Di-tert-butyl dicarbonate;Di-tert-butyl dicarbonate, Di-tert-butyl pyrocarbonate

CAS NO.：24424-99-5

Empirical Formula: C10H18O5

Molecular Weight: 218.25

MDL number: MFCD00008805

EINECS: 246-240-1

PRODUCT Properties

• Melting point: 23 °C (lit.)
• Boiling point: 56-57 °C/0.5 mmHg (lit.)
• Density: 0.95 g/mL at 25 °C (lit.)
• vapor pressure: 3.85Pa at 25℃
• refractive index: n20/D 1.409(lit.)
• Flash point: 99 °F
• storage temp.: 2-8°C
• solubility: Chloroform (Sparingly), Methanol (Slightly)
• form: Low Melting Crystalline Solid
• color: White
• Specific Gravity: 0.950
• Water Solubility: Miscible with decalin, toluene, carbon tetrachloride, tetrahydrofuran, dioxane, alcohols, acetone, acetonitrile and dimethylformamide. Immiscible with water.
• Sensitive: Moisture Sensitive
• BRN: 1911173
• Stability: Acid Sensitive
• InChIKey: DYHSDKLCOJIUFX-UHFFFAOYSA-N
• LogP: 1.87 at 25℃

Description and Uses

Di-tert-butyl dicarbonate (Boc2O) is a widely used reagent for introducing protecting groups in peptide synthesis. It plays an important role in the preparation of 6-acetyl-1,2,3,4-tetrahydropyridine by reacting with 2-piperidone. It serves as a protecting group used in solid phase peptide synthesis.

Safety

• Symbol(GHS): GHS02,GHS05,GHS06
• Signal word: Danger
• Hazard statements: H226-H315-H317-H318-H330-H335
• Precautionary statements: P210-P233-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
• Hazard Codes: T+,T,F,Xi,F+
• Risk Statements: 11-19-26-36/37/38-43-10-40
• Safety Statements: 16-26-28-36/37-45-7/9-37/39-24-36/37/39-33
• RIDADR: UN 2929 6.1/PG 1
• WGK Germany: 3
• RTECS: HT0230000
• F: 4.4-10-21
• Autoignition Temperature: 460 °C
• Hazard Note: Flammable/Irritant/Very Toxic
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: I
• HS Code: 29209010
• Toxicity: LD50 orally in Rabbit: > 5000 mg/kg LD50 dermal Rabbit > 2000 mg/kg