Home Categories Biochemical Engineering Di-tert-butyl dicarbonate
A3155612

Di-tert-butyl dicarbonate , 98% , 24424-99-5

Synonym(s):
Boc anhydride;Boc2O;Di-tert-butyl pyrocarbonate;Di-tert-butyl dicarbonate;Di-tert-butyl dicarbonate, Di-tert-butyl pyrocarbonate

CAS NO.:24424-99-5

Empirical Formula: C10H18O5

Molecular Weight: 218.25

MDL number: MFCD00008805

EINECS: 246-240-1

Pack Size Price Stock Quantity
25G RMB28.00 In Stock
100G RMB40.80 In Stock
500G RMB159.20 In Stock
2.5KG RMB711.20 In Stock
5kg RMB1279.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 23 °C (lit.)
Boiling point: 56-57 °C/0.5 mmHg (lit.)
Density  0.95 g/mL at 25 °C (lit.)
vapor pressure  3.85Pa at 25℃
refractive index  n20/D 1.409(lit.)
Flash point: 99 °F
storage temp.  2-8°C
solubility  Chloroform (Sparingly), Methanol (Slightly)
form  Low Melting Crystalline Solid
color  White
Specific Gravity 0.950
Water Solubility  Miscible with decalin, toluene, carbon tetrachloride, tetrahydrofuran, dioxane, alcohols, acetone, acetonitrile and dimethylformamide. Immiscible with water.
Sensitive  Moisture Sensitive
BRN  1911173
Stability: Acid Sensitive
InChIKey DYHSDKLCOJIUFX-UHFFFAOYSA-N
LogP 1.87 at 25℃

Description and Uses

Di-tert-butyl dicarbonate (Boc2O) is a widely used reagent for introducing protecting groups in peptide synthesis. It plays an important role in the preparation of 6-acetyl-1,2,3,4-tetrahydropyridine by reacting with 2-piperidone. It serves as a protecting group used in solid phase peptide synthesis.

Safety

Symbol(GHS) 
GHS02,GHS05,GHS06
Signal word  Danger
Hazard statements  H226-H315-H317-H318-H330-H335
Precautionary statements  P210-P233-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
Hazard Codes  T+,T,F,Xi,F+
Risk Statements  11-19-26-36/37/38-43-10-40
Safety Statements  16-26-28-36/37-45-7/9-37/39-24-36/37/39-33
RIDADR  UN 2929 6.1/PG 1
WGK Germany  3
RTECS  HT0230000
4.4-10-21
Autoignition Temperature 460 °C
Hazard Note  Flammable/Irritant/Very Toxic
TSCA  Yes
HazardClass  6.1
PackingGroup  I
HS Code  29209010
Toxicity LD50 orally in Rabbit: > 5000 mg/kg LD50 dermal Rabbit > 2000 mg/kg

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