Home Categories Organic Chemistry Dichloroacetic acid
A3137312

Dichloroacetic acid , AR,98% , 79-43-6

Synonym(s):
DCA Deblock;DEBLOCK (0.36M dichloroacetic acid in toluene);Dichloroacetic acid

CAS NO.:79-43-6

Empirical Formula: C2H2Cl2O2

Molecular Weight: 128.94

MDL number: MFCD00004223

EINECS: 201-207-0

Update time: 2022-07-08

PRODUCT Properties

Melting point: 9-11 °C(lit.)
Boiling point: 194 °C(lit.)
Density  1.56 g/mL at 25 °C (lit.)
vapor density  4.5 (vs air)
vapor pressure  0.19 mm Hg ( 20 °C)
refractive index  n20/D 1.466(lit.)
Flash point: >230 °F
storage temp.  Store below +30°C.
solubility  Chloroform (Slightly), Methanol (Slightly)
pka 1.48(at 25℃)
form  Liquid
color  APHA: <50
PH 1.2 (129g/l, H2O, 20℃)
Water Solubility  soluble
Sensitive  Hygroscopic
Merck  14,3050
BRN  1098596
Exposure limits ACGIH: TWA 0.5 ppm (Skin)
Dielectric constant 10.7(-7℃)
Stability: Stable. Incompatible with strong oxidizing agents, strong bases, strong reducing agents. Reacts with water. Protect from moisture. Hygroscopic.
InChIKey JXTHNDFMNIQAHM-UHFFFAOYSA-N
LogP 0.92

Description and Uses

DCA is a corrosive, combustible, colorless liquid with a pungent odor. Molecular weight = 128.94;Specific gravity (H2O:1) = 1.56; Boiling point = 193.8℃;Freezing/Melting point = 9.7-13.5℃; Vaporpressure = 1 mmHg at 44℃; Flash point = 110℃. HazardIdentification (based on NFPA-704 M Rating System):Health 3, Flammability 1, Reactivity 1. Highly corrosive.Soluble in water.

Dichloroacetic acid is used as an intermediate to make other chemicals such as its salts and esters. It is involved as a test reagent for fiber analysis and a disinfectant. It is used to inhibit mitochondrial PDK (pyruvate dehydrogenase kinase) and to shift cellular metabolism from glycolysis to glucose oxidation. Further, it is used in the treatment for post-ischemic recovery.

Safety

Symbol(GHS) 
GHS05,GHS06,GHS08,GHS09
Signal word  Danger
Hazard statements  H290-H311-H314-H351-H360FD-H373-H400
Precautionary statements  P202-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
Hazard Codes  Xn,N,C,Xi,F
Risk Statements  36/38-40-50-35-36/37/38-67-38-65-48/20-11-63-50/53
Safety Statements  26-45-61-36/37-36-16-62-36/37/39
RIDADR  UN 1764 8/PG 2
WGK Germany  2
RTECS  AG6125000
3-10
TSCA  Yes
HS Code  2915 40 00
HazardClass  8
PackingGroup  II
Toxicity LD50 orally in rats: 2.82 g/kg (Smyth)

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