Home Categories Biochemical Engineering Deoxycholic acid
A3134512

Deoxycholic acid , 98% , 83-44-3

Synonym(s):
3α,12α-Dihydroxy-5β-cholanic acid;7-Deoxycholic acid;Deoxycholic acid;Desoxycholic acid

CAS NO.:83-44-3

Empirical Formula: C24H40O4

Molecular Weight: 392.58

MDL number: MFCD00003673

EINECS: 201-478-5

Pack Size Price Stock Quantity
5g RMB35.20 In Stock
25G RMB155.20 In Stock
100G RMB388.00 In Stock
500G RMB1808.80 In Stock
2.5kg RMB11199.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 171-174 °C(lit.)
Boiling point: 437.26°C (rough estimate)
alpha  55 º (c=1, EtOH)
Density  0.9985 (rough estimate)
vapor pressure  0.004Pa at 20℃
refractive index  1.4460 (estimate)
Flash point: 9℃
storage temp.  room temp
solubility  0.24 g/L (15°C)
pka 5.15(at 20℃)
form  Solid
color  White to Off-White
optical activity [α]20/D +54±1°, c = 1% in ethanol
Water Solubility  0.24 g/L (15 ºC)
Merck  14,2899
BRN  3219882
Stability: Stable. Combustible. Incompatible with strong oxidizing agents.
LogP 5.34 at 22℃ and pH5.7
Surface tension 54mN/m at 51.3mg/L and 20℃

Description and Uses

Deoxycholic acid sodium salt, which is a secondary bile acid and the metabolite of intestinal bacteria, provides a nonsurgical treatment to significantly reduce submental fat in adults via injection directly into moderate-to-severe fatty tissue below the neck. When injected into fatty tissue, deoxycholic acid helps destroy fat cells. Although deoxycholic acid has many applications beyond human health, the application as a dyslipidemia drug was licensed to Kythera from Los Angeles Biomedical Institute at Harbor-UCLA Medical Center in 2007. Allergan acquired Kythera recently in 2015.

Deoxycholic acid has been used in a modified procedure to recover 40-80% of a protein from a 1 μg/mL solution. It forms complexes with fatty acid. Used as an emulsifying agent in food, a precursor in the synthesis of cortisone, and a gallbladder stimulant. It has been used to study assess how physiological concentrations of ursodeoxycholic acid (UDCA) vs. deoxycholic acid (DCA) affect barrier function in mouse intestinal tissue. Deoxycholic acid has been used in a study to assess a pH-Responsive Mechanism of a Deoxycholic Acid and Folate Co-Modified Chitosan Micelle under Cancerous Environment. It has also been used in a study to investigate dose-dependent anti-inflammatory effect of ursodeoxycholic acid in experimental colitis.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
Hazard Codes  Xn
Risk Statements  22-36/37/38-37-20/21/22
Safety Statements  26-36-37/39-22
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  3
RTECS  FZ2100000
TSCA  Yes
HS Code  29181990
Toxicity LD50 oral in rat: 1gm/kg

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