2-(Dicyclohexylphosphino)biphenyl , 98% , 247940-06-3

Synonym(s):
(2-Biphenyl)dicyclohexylphosphine;2-(Dicyclohexylphosphino)biphenyl;Cyclohexyl JohnPhos

CAS NO.：247940-06-3

Empirical Formula: C24H31P

Molecular Weight: 350.48

MDL number: MFCD01862441

EINECS: 480-030-2

PRODUCT Properties

• Melting point: 102-106 °C(lit.)
• Boiling point: 499.5±24.0 °C(Predicted)
• storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
• solubility: soluble in Toluene
• form: crystal
• color: white
• Sensitive: Air Sensitive
• BRN: 8440533
• InChI: InChI=1S/C24H31P/c1-4-12-20(13-5-1)23-18-10-11-19-24(23)25(21-14-6-2-7-15-21)22-16-8-3-9-17-22/h1,4-5,10-13,18-19,21-22H,2-3,6-9,14-17H2
• InChIKey: LCSNDSFWVKMJCT-UHFFFAOYSA-N
• SMILES: P(C1=CC=CC=C1C1=CC=CC=C1)(C1CCCCC1)C1CCCCC1
• CAS DataBase Reference: 247940-06-3(CAS DataBase Reference)

Description and Uses

2-(Dicyclohexylphosphino)biphenyl is a ligand for the amination of triflates and aryl halides. Optimal ligand for a novel amination reaction (Buchwald reaction)(2) 2-(Dicyclohexylphosphino)biphenyl, a synthetic chemical compound, has found diverse applications in scientific research. Being a cyclic phosphonate derivative of cyclohexanol, this colourless, odourless, and tasteless solid holds a distinct appeal for laboratory use. In scientific research, 2-(Dicyclohexylphosphino)biphenyl has proven invaluable. It serves as an excellent model compound for delving into protein-ligand interactions, thus aiding in studying small molecule effects on protein folding. Moreover, researchers have utilized 2-(Dicyclohexylphosphino)biphenyl to gain insights into protein structures and unravel the mechanism of action behind various drugs. Additionally, the compound has been a vital tool in assessing how environmental factors influence protein structure and function. The interaction between 2-(Dicyclohexylphosphino)biphenyl and proteins primarily occurs through hydrogen bonding and hydrophobic interactions, resulting in high-affinity and specific protein binding. 

suzuki reaction

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H413
• Precautionary statements: P261-P280-P305+P351+P338-P304+P340-P405-P501A
• Hazard Codes: Xn
• Risk Statements: 36/37/38-22
• Safety Statements: 36/37/39-26
• WGK Germany: 3
• F: 10-13-23
• TSCA: No
• HazardClass: AIR SENSITIVE
• HS Code: 29310099