PRODUCT Properties
| Boiling point: | 116 °C(lit.) |
| Density | 1.626 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | >230 °F |
| pka | -9.30±0.39(Predicted) |
| form | Liquid |
| color | Clear colorless |
| Specific Gravity | 1.626 |
| BRN | 610168 |
Description and Uses
5-Chloro-2,4,6-trifluoropyrimidine can be used as a starting material to synthesize:
- 4-azido-5-chloro-2,6-difluoro-pyrimidine by azidation reaction with sodium azide.
- 5-chloro triphenoxy pyrimidine by reacting with tetraphenoxysilane in the presence of tetra butyl ammonium fluoride (TBAF).
- 5-chloro-2,6-difluoropyrimidin-4-amine, and 5-chloro-4,6-difluoropyrimidin-2-amine (9:1 ratio) by reacting with ammonia.
- 5-Chloro-N,N -diethyl-2,6-dipyrimidin-4-amine, by treating with diethylamine and DIPEA.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36-37/39 |
| WGK Germany | 3 |
| Hazard Note | Irritant |
| HazardClass | IRRITANT, MOISTURE SENSITIVE |
| HS Code | 29335990 |
