A2681112
3-<WBR>(Cyclopropylmethoxy)<WBR>-<WBR>4-<WBR>(difluoromethoxy)<WBR>benzoic acid , 98% , 162401-62-9
CAS NO.:162401-62-9
Empirical Formula: C12H12F2O4
Molecular Weight: 258.22
MDL number: MFCD04621687
EINECS: 605-288-7
Pack Size | Price | Stock | Quantity |
250mg | RMB52.00 | In Stock |
|
1G | RMB112.80 | In Stock |
|
5g | RMB332.80 | In Stock |
|
10g | RMB566.40 | In Stock |
|
25g | RMB1496.80 | In Stock |
|
others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
Melting point: | 118-120℃ |
Boiling point: | 356.4±37.0 °C(Predicted) |
Density | 1.355±0.06 g/cm3(Predicted) |
storage temp. | Sealed in dry,Room Temperature |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
pka | 3.87±0.10(Predicted) |
color | White to Off-White |
InChI | InChI=1S/C12H12F2O4/c13-12(14)18-9-4-3-8(11(15)16)5-10(9)17-6-7-1-2-7/h3-5,7,12H,1-2,6H2,(H,15,16) |
InChIKey | IGFDIFLMMLWKKY-UHFFFAOYSA-N |
SMILES | C(O)(=O)C1=CC=C(OC(F)F)C(OCC2CC2)=C1 |
CAS DataBase Reference | 162401-62-9 |
Description and Uses
3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid (DGM) is a pharmaceutical intermediate ingredient used in the preparation of Roflumilast, a selective phosphodiesterase-4 (PDE4) inhibitor approved for the treatment of chronic bronchitis and to reduce the risk of exacerbations in patients with severe chronic obstructive pulmonary disease (COPD).
An impurity and intermediate in the preparation of selective phosphodiesterase 4 (PDE4) inhibitor, Roflumilast (R639700).