Climbazol , 98% , 38083-17-9

Synonym(s):
1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutan-2-one

CAS NO.：38083-17-9

Empirical Formula: C15H17ClN2O2

Molecular Weight: 292.76

MDL number: MFCD00055505

EINECS: 253-775-4

PRODUCT Properties

• Melting point: 96-100°C
• Boiling point: 447.5±40.0 °C(Predicted)
• Density: 1.17±0.1 g/cm3(Predicted)
• vapor pressure: 0.001Pa at 25℃
• refractive index: 1.54
• storage temp.: Inert atmosphere,Room Temperature
• solubility: Insoluble in water
• form: Solid
• pka: 5.66±0.22(Predicted)
• color: White to Almost white
• Water Solubility: 58mg/L at 25℃
• BRN: 618020
• InChIKey: OWEGWHBOCFMBLP-UHFFFAOYSA-N
• LogP: 3.83 at 25℃
• CAS DataBase Reference: 38083-17-9(CAS DataBase Reference)

Description and Uses

(±)-Climbazole is an imidazole antifungal agent. It inhibits the growth of C. albicans (MIC = 0.29 μg/ml), as well as clinical isolates of M. pachydermatis (MICs = <0.06-1 μg/ml) and M. furfur (MICs = <0.06-0.5 μg/ml) in vitro. It also reduces the size of Malassezia populations on the skin of naturally infected dogs when used at a dose of 2% in shampoo. (±)-Climbazole (80 mg/kg) increases the levels of cytochrome P450 in rat liver. Formulations containing climbazole have been used in the treatment of dandruff.

Climbazole is an imidazole antifungal agent that can provide anti-dandruff benefits when incorporated into a shampoo matrix. s assay and did not induce micronuclei in human lymphocytes.

Safety

• Symbol(GHS): GHS07,GHS09
• Signal word: Warning
• Hazard statements: H302-H410
• Precautionary statements: P301+P312+P330
• Hazard Codes: Xn,N
• Risk Statements: 22-50/53
• Safety Statements: 60-61
• RIDADR: UN 3077
• WGK Germany: 3
• RTECS: EL7085000
• HS Code: 29332900