Chlormadinone Acetate , >97.0%(HPLC) , 302-22-7

Synonym(s):
17α-Acetoxy-6-chloro-4,6-pregnadiene-3,20-dione;6-Chloro-17α-hydroxy-4,6-pregnadiene-3,20-dione 17-acetate;6-Chloro-6-dehydro-17α-acetoxyprogesterone;Gestafortin;Matrol

CAS NO.：302-22-7

Empirical Formula: C23H29ClO4

Molecular Weight: 404.93

MDL number: MFCD00056471

EINECS: 206-118-0

PRODUCT Properties

• Melting point: 212°C
• alpha: D +6° (c = 1 in CHCl3)
• Boiling point: 512.5±50.0 °C(Predicted)
• Density: 1.1345 (estimate)
• storage temp.: Sealed in dry,Store in freezer, under -20°C
• solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• form: Solid
• color: Off-White to Light Yellow
• λmax: 285nm(EtOH)(lit.)
• Merck: 14,2102
• BRN: 2633614

Description and Uses

Chlormadinone acetate is a synthetic progestin. It binds to progesterone, androgen, and glucocorticoid receptors in vitro (K_is = 2.5, 3.8, and 16 nM, respectively, for the human receptors). Chlormadinone acetate increases the number of endometrial glands and uterine weight in β-estradiol-primed rabbits when administered at a dose of 45 μg/kg per day for five days. Chlormadinone acetate reduces testosterone-induced increases in the seminal vesicle weight of castrated male rats when administered at doses of 4.6 and 21.5 mg/kg per day for eight days.

Orally active progesteron with antiandrogenic activity; has been used in combinations as an oral contraceptive. Progestogen; antineoplastic (hormonal).

Safety

• Symbol(GHS): GHS08
• Signal word: Danger
• Hazard statements: H351-H360
• Precautionary statements: P202-P405-P501-P201-P280-P308+P313-P281
• Hazard Codes: T
• Risk Statements: 60-61-40-48
• Safety Statements: 53-22-36/37/39-45
• WGK Germany: 3
• RTECS: TU3750000
• HS Code: 29372390
• Toxicity: mouse,LD50,intraperitoneal,3gm/kg (3000mg/kg),ENDOCRINE: ADRENAL CORTEX HYPOPLASIABEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),Kiso to Rinsho. Clinical Report. Vol. 11, Pg. 571, 1977.