Chlormadinone Acetate , >97.0%(HPLC) , 302-22-7
Synonym(s):
17α-Acetoxy-6-chloro-4,6-pregnadiene-3,20-dione;6-Chloro-17α-hydroxy-4,6-pregnadiene-3,20-dione 17-acetate;6-Chloro-6-dehydro-17α-acetoxyprogesterone;Gestafortin;Matrol
CAS NO.：302-22-7
Empirical Formula: C23H29ClO4
Molecular Weight: 404.93
MDL number: MFCD00056471
EINECS: 206-118-0
| Pack Size | Price | Stock | Quantity |
| 1G | RMB116.80 | In Stock |
|
| 5G | RMB385.60 | In Stock |
|
| 25g | RMB1092.80 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 212°C |
| alpha | D +6° (c = 1 in CHCl3) |
| Boiling point: | 512.5±50.0 °C(Predicted) |
| Density | 1.1345 (estimate) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| form | Solid |
| color | Off-White to Light Yellow |
| λmax | 285nm(EtOH)(lit.) |
| Merck | 14,2102 |
| BRN | 2633614 |
| NIST Chemistry Reference | Chlormadinone acetate(302-22-7) |
| EPA Substance Registry System | Pregna-4,6-diene-3,20-dione, 17-(acetyloxy)-6-chloro- (302-22-7) |
Description and Uses
Chlormadinone acetate is a synthetic progestin. It binds to progesterone, androgen, and glucocorticoid receptors in vitro (Kis = 2.5, 3.8, and 16 nM, respectively, for the human receptors). Chlormadinone acetate increases the number of endometrial glands and uterine weight in β-estradiol-primed rabbits when administered at a dose of 45 μg/kg per day for five days. Chlormadinone acetate reduces testosterone-induced increases in the seminal vesicle weight of castrated male rats when administered at doses of 4.6 and 21.5 mg/kg per day for eight days.
Orally active progesteron with antiandrogenic activity; has been used in combinations as an oral contraceptive. Progestogen; antineoplastic (hormonal).
Safety
| Symbol(GHS) |  GHS08 |
| Signal word | Danger |
| Hazard statements | H351-H360 |
| Precautionary statements | P202-P405-P501-P201-P280-P308+P313-P281 |
| Hazard Codes | T |
| Risk Statements | 60-61-40-48 |
| Safety Statements | 53-22-36/37/39-45 |
| WGK Germany | 3 |
| RTECS | TU3750000 |
| HS Code | 29372390 |
| Hazardous Substances Data | 302-22-7(Hazardous Substances Data) |
| Toxicity | mouse,LD50,intraperitoneal,3gm/kg (3000mg/kg),ENDOCRINE: ADRENAL CORTEX HYPOPLASIABEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),Kiso to Rinsho. Clinical Report. Vol. 11, Pg. 571, 1977. |
