Home Categories Biochemical Engineering Cholesteryl hemisuccinate
A2488812

Cholesteryl hemisuccinate , ≥97.0% , 1510-21-0

Synonym(s):
3β-Hydroxy-5-cholestene 3-hemisuccinate;5-Cholesten-3β-ol 3-hemisuccinate;Cholesteryl hydrogen succinate

CAS NO.:1510-21-0

Empirical Formula: C31H50O4

Molecular Weight: 486.73

MDL number: MFCD00037705

EINECS: 216-148-6

Pack Size Price Stock Quantity
1g RMB149.60 In Stock
5G RMB479.20 In Stock
25G RMB1874.40 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 178 °C
Boiling point: 586.0±43.0 °C(Predicted)
Density  1.06±0.1 g/cm3(Predicted)
refractive index  -34 ° (C=2, CHCl3)
storage temp.  -20°C
solubility  Chloroform (Slightly), Methanol (Slightly, Heated, Sonicated)
form  Solid
pka 4.40±0.17(Predicted)
color  White to Off-White
InChIKey WLNARFZDISHUGS-BLYFUZNHSA-N
LogP 10.708 (est)
CAS DataBase Reference 1510-21-0(CAS DataBase Reference)

Description and Uses

Cholesteryl hemisuccinate is a cholesterol ester with anticancer activity. It inhibits the growth of murine C1498 myeloid and L1210 lymphocytic leukemia cells when used at concentrations of 50 and 150 μM, respectively. Cholesteryl hemisuccinate acts as an ionizable anionic detergent and is commonly used to stabilize unilamellar vesicles and liposomes. It has also been used as an emulsifying agent in various vesicular drug delivery systems for anticancer drugs, antibiotics, and oligonucleotides and to solubilize various proteins including chemokine receptor 1 as well as erythrocyte ghosts.

Cholesteryl Hemisuccinate is an oxidation product of polyunsaturated fatty acid of cholesterol that alters lysosome structure and functions and induces proinflammatory cytokine production in macrophages.

Safety

WGK Germany  3
HS Code  29171900

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