4-cholesten-3-one , >98% , 601-57-0

Synonym(s):
110829;3-Keto-4-cholestene;3-Oxo-4-cholestene;4-Cholesten-3-one

CAS NO.：601-57-0

Empirical Formula: C27H44O

Molecular Weight: 384.64

MDL number: MFCD00003663

EINECS: 210-005-1

PRODUCT Properties

• Melting point: 79-82 °C
• Boiling point: 451.27°C (rough estimate)
• alpha: 92.5 º (c=2, CHCl3)
• Density: 0.9717 (rough estimate)
• refractive index: 1.5100 (estimate)
• storage temp.: -20°C
• solubility: Chloroform (Sparingly), Methanol (Slightly, Heated)
• form: Solid
• color: White to Off-White
• optical activity: [α]23/D +91.0°, c = 2 in chloroform
• Water Solubility: <0.5 g/L
• BRN: 4707774
• Stability: Stable. Incompatible with strong oxidizing agents.

Description and Uses

Cholestanone is a cholesterol metabolite that has a keto group in place of the 3-hydroxy group on cholesterol. It decreases TGF-β-induced Smad2 phosphorylation and TGF-β expression and prevents inhibition of DNA synthesis by TGF-β in Mv1Lu cells when used at a concentration of 50 μg/ml. Increased fecal excretion of cholestenone is correlated with an increased risk of colorectal cancer. Cholestenone reduces serum cholesterol levels in a variety of animal models but is toxic to rats when administered at doses of 700-1,000 mg/kg per day, inducing hypertrophy in and reducing the activity of the adrenal gland. It has been used as synthetic intermediate in the synthesis of steroids.

4-Cholesten-3-one is used as a chiral building block for proteomics research. It is an intestinal metabolite of cholesterol and exhibits an anti-obesity effect on animals.

Safety

• Hazard statements: H413
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 22-24/25-36-26
• WGK Germany: 3
• RTECS: FZ7700000
• TSCA: Yes
• HS Code: 29142900