Clarithromycin , ≥98% , 81103-11-9

Synonym(s):
6-O-methyl erythromycin;CLM

CAS NO.：81103-11-9

Empirical Formula: C38H69NO13

Molecular Weight: 747.95

MDL number: MFCD00865140

EINECS: 1806241-263-5

PRODUCT Properties

• Melting point: 217-220°C
• Boiling point: 86℃
• alpha: D24 -90.4° (c = 1 in CHCl3)
• Density: 1.1334 (rough estimate)
• refractive index: -92 ° (C=1, CHCl3)
• Flash point: >110°(230°F)
• storage temp.: -20°C
• solubility: Soluble in DMSO
• pka: pKa 8.99(H2O t=25.0 I=0.167) (Uncertain)
• form: powder
• color: colorless to faint yellow
• Water Solubility: 99.48mg/L(20 ºC)
• Merck: 14,2339
• BCS Class: 4
• Stability: Store in Freezer
• InChIKey: AGOYDEPGAOXOCK-KCBOHYOISA-N
• EPA Substance Registry System: Erythromycin, 6-O-methyl- (81103-11-9)

Description and Uses

Clarithromycin is an acid stable macrolide antibiotic indicated for use in the treatment of skin, urinary and respiratory tract infections. Compared to erythromycin, clarithromycin exhibits the same in vitro activity against conventional pathogens, but is better tolerated by generating less gastrointestinal problems.

A macrolide antibiotic and protein synthesis inhibitor

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P264-P270-P301+P312-P501
• Hazard Codes: Xn,Xi
• Risk Statements: 22-36/37/38
• Safety Statements: 26-36-60
• WGK Germany: 3
• RTECS: KF4997000
• HS Code: 29419000
• Hazardous Substances Data: 81103-11-9(Hazardous Substances Data)
• Toxicity: LD50 in male, female mice, male, female rats (mg/kg): 2740, 2700, 3470, 2700 orally, 1030, 850, 669, 753 i.p., >5000 all s.c. (Abe)