Clomipramine HCl , ≥99% , 17321-77-6

Synonym(s):
3-Chloro-10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride;Anafranil hydrochloride;Clomipramine hydrochloride

CAS NO.：17321-77-6

Empirical Formula: C19H24Cl2N2

Molecular Weight: 351.31

MDL number: MFCD00069234

EINECS: 241-344-3

PRODUCT Properties

• Melting point: 189-190°C
• Flash point: 9℃
• storage temp.: 2-8°C
• solubility: H₂O: 25 mg/mL
• form: powder
• color: white to off-white
• PH: 3.5～5.0（100g/l，25℃）
• BCS Class: 3/1
• InChIKey: WIMWMKZEIBHDTH-UHFFFAOYSA-N
• CAS DataBase Reference: 17321-77-6(CAS DataBase Reference)

Description and Uses

Clomipramine is a tricyclic antidepressant, the 3-chlorinated derivative of imipramine . Like imipramine, clomipramine potently inhibits serotonin and norepinephrine reuptake (K_is = 7.4 and 96 nM, respectively). It also is an antagonist at histamine, muscarinic acetylcholine, α₁-adrenergic, and dopamine receptors (K_ds = 31, 37, 38, and 190 nM for H₁, M₁, α₁, and D₂, respectively).

Potent, selective 5-HT uptake blocker

Safety

• Symbol(GHS): GHS07,GHS08,GHS09
• Signal word: Danger
• Hazard statements: H302-H336-H370-H410
• Precautionary statements: P260-P264-P270-P273-P301+P312-P308+P311
• Hazard Codes: Xn,T,F
• Risk Statements: 20/21/22-39/23/24/25-23/24/25-11-36/37/38
• Safety Statements: 36-45-36/37-16-7-62-38-36/37/39-28-26-24/25-22-20/21-13
• RIDADR: 3249
• WGK Germany: 3
• RTECS: HN9055000
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 2933996100