Ceftiofur HCl , ≥95% , 103980-44-5

Synonym(s):
;3-[(2-Furylcarbonyl)thio]methyl]-7-[2-(2-amino-4-thiazolyl)-2-(methoxyiminoacetamido)-3-cephem-4-carboxylic acid hydrochloride;Ceftiofur hydrochloride

CAS NO.：103980-44-5

Empirical Formula: C19H18ClN5O7S3

Molecular Weight: 560.01

MDL number: MFCD04038020

EINECS: 600-507-2

PRODUCT Properties

• Melting point: >190°C (dec.)
• alpha: -92～-98°(D/20℃)(c=0.2,CH3OH)
• storage temp.: Inert atmosphere,2-8°C
• solubility: DMSO (Slightly), Methanol (Slightly)
• color: Off-White
• InChIKey: KEQFDTJEEQKVLM-JUODUXDSSA-N
• SMILES: C(C1=C(CS[C@]2([H])[C@H](NC(=O)/C(/C3N=C(N)SC=3)=N\OC)C(=O)N12)CSC(C1OC=CC=1)=O)(=O)O.Cl |&1:5,7,r|

Description and Uses

Ceftiofur Hydrochloride is the hydrochloride salt form of ceftiofur, a semisynthetic, beta-lactamase-stable, broad-spectrum, third-generation cephalosporin with antibacterial activity. Ceftiofur binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

Ceftiofur hydrochloride (ceftiofur) has been approved for treatment against respiratory diseases in many animals.1,3,8–10 The recommended dosage regimen of ceftiofur for the treatment of swine respiratory disease is 3–5 mg/kg body weight (BW) administered intramuscularly once daily for 3–5 consecutive days.

Safety

• Symbol(GHS): GHS07,GHS08,GHS09
• Signal word: Danger
• Hazard statements: H315-H319-H335-H410-H372
• Precautionary statements: P210-P261-P264-P271-P273-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P370+P378-P403+P233-P403+P235-P405-P501
• WGK Germany: 3
• HS Code: 2941906000