Cabazitaxel , ≥99% , 183133-96-2
Synonym(s):
;DEP cabazitaxel;dimethoxydocetaxel;Jevtana
CAS NO.：183133-96-2
Empirical Formula: C45H57NO14
Molecular Weight: 835.93
MDL number: MFCD18827611
EINECS: 680-632-7
| Pack Size | Price | Stock | Quantity |
| 10MG | RMB87.20 | In Stock |
|
| 25mg | RMB175.20 | In Stock |
|
| 50MG | RMB279.20 | In Stock |
|
| 100mg | RMB439.20 | In Stock |
|
| 250MG | RMB863.20 | In Stock |
|
| 500mg | RMB1719.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 180 °C |
| Boiling point: | 870.7±65.0 °C(Predicted) |
| Density | 1.31 |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | White solid. |
| pka | 11.20±0.46(Predicted) |
| color | White to Off-White |
| InChIKey | BMQGVNUXMIRLCK-JACFBOAKNA-N |
Description and Uses
In June 2010, the U.S. FDA approved cabazitaxel (also referred to as
XRP6258 and RPR 116258A) in combination with the steroid prednisone
for the treatment of metastatic Castration-Resistant Prostate Cancer
(mCRPC) for patients who were previously treated with a docetaxelcontaining
regimen for late-stage disease.
Cabazitaxel is a semisynthetic analog of the
natural product taxol, which is isolated from the bark of the yew tree.
Cabazitaxel is a microtubule inhibitor that binds to the taxol-binding site of
tubulin. Similar to other tubulin inhibitors of the taxol class, cabazitaxel
inhibits microtubule disassembly resulting in mitotic blockade and cell
death. Docetaxel, also a semisynthetic taxol analog, was approved by the
FDA for the treatment of mCRPC in 2004. However, docetaxel is a substrate
for P-gp, which is thought to contribute to the constitutive and acquired
resistance of cancer cells to taxanes. Cabazitaxel has poor affinity for P-gp
and showed antitumor activity in preclinical in vitro studies and in vivo
tumor models that overexpress this protein. Cabazitaxel is synthesized on
a commercial scale from 10-deacetylbaccatin .
A novel semi-synthetic taxane with antitumor activity used for the treatment of castration-resistant prostate cancer. A microtubule inhibitor.
Safety
| Symbol(GHS) |   GHS07,GHS08 |
| Signal word | Warning |
| Hazard statements | H302-H315-H341-H361fd-H373 |
| Precautionary statements | P202-P260-P264-P301+P312-P302+P352-P308+P313 |
| Safety Statements | 24/25 |
| HS Code | 29329990 |
