CO-1686 (AVL-301) , ≥99% , 1374640-70-6

CAS NO.：1374640-70-6

Empirical Formula: C27H28F3N7O3

Molecular Weight: 555.55

MDL number: MFCD26793864

PRODUCT Properties

• Melting point: 202 - 205°C (dec.)
• Density: 1.372±0.06 g/cm3(Predicted)
• storage temp.: Amber Vial, -20°C Freezer, Under inert atmosphere
• solubility: DMSO (Slightly), Methanol (Slightly)
• form: Solid
• pka: 13.23±0.70(Predicted)
• color: Off-White

Description and Uses

CO-1686 is an irreversible kinase inhibitor that specifically targets mutant forms of the epidermal growth factor receptor (EGFR) including T790M (K_i = 21.5 nM) with significantly reduced activity at the wild-type form of the receptor (K_i = 303.3 nM). CO-1686 has been shown to inhibit the proliferation of non-small cell lung cancer (NSCLC) cells expressing mutant EGFR with GI₅₀ values ranging from 7-32 nM in vitro, inducing apoptosis. It also demonstrates anti-tumor activity in NSCLC EGFR mutant xenograft and transgenic models dosed orally at 100 mg/kg/day.

CO 1686 is seen as an irreversible epidermal growth factor receptor (EFGR1) kinase inhibitor.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501
• Risk Statements: 23-25-36
• Safety Statements: 24
• HS Code: 29335990