4-(3-Chloropropyl)morpholine , ≥98%(GC) , 7357-67-7

CAS NO.：7357-67-7

Empirical Formula: C7H14ClNO

Molecular Weight: 163.65

MDL number: MFCD00035333

EINECS: 461-510-0

PRODUCT Properties

• Melting point: NA
• Boiling point: 115°C/25mmHg(lit.)
• Density: 1.0409 g/cm3
• RTECS: QE0488000
• refractive index: 1.4720-1.4760
• Flash point: 91 °C
• storage temp.: Inert atmosphere,Store in freezer, under -20°C
• solubility: Chloroform (Slightly), Methanol (Slightly)
• form: Oil
• pka: 7.03±0.10(Predicted)
• Specific Gravity: 1.08
• color: Colourless to Yellow
• InChI: InChI=1S/C7H14ClNO/c8-2-1-3-9-4-6-10-7-5-9/h1-7H2
• InChIKey: PQECODMSWJOUAT-UHFFFAOYSA-N
• SMILES: N1(CCCCl)CCOCC1
• CAS DataBase Reference: 7357-67-7(CAS DataBase Reference)

Description and Uses

4-(3-Chloropropyl)morpholine is a hydrochloride salt of the potent inhibitor 4-(3-chloropropyl)morpholine. It has an inhibitory effect on cancer, and is used in chromatographic science to separate amines from aliphatic hydrocarbons. 4-(3-Chloropropyl)morpholine inhibits epidermal growth factor (EGF) and has been shown to have a potent inhibitory effect on EGF receptor tyrosine kinase activity. It also inhibits the proliferation of cells by inhibiting DNA synthesis. This compound causes cell death through the inhibition of protein synthesis, which may be due to its ability to inhibit nucleophilic reactions that are involved in protein synthesis. 4-(3-Chloropropyl)morpholine can also fluoresce under UV light, which makes it useful for research purposes.

Gefitinib intermediate.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H335-H315-H319
• Precautionary statements: P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a
• Risk Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• HS Code: 2934999090