PRODUCT Properties
| Boiling point: | 98C/19Torr |
| Density | 1.45 |
| refractive index | 1.561-1.563 |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| form | Liquid |
| pka | 2.52±0.10(Predicted) |
| color | Clear light yellow to orange |
| CAS DataBase Reference | 4863-91-6(CAS DataBase Reference) |
Description and Uses
3-Chloro-5-fluoroaniline is an aniline derivative with chlorine and fluorine substituents at positions 3 and 5, respectively, which can be used as a reagent for chemical reactions, as a raw material for organic synthesis, and as a component of pharmaceutical intermediates. It is widely used in the synthesis of active pharmaceutical ingredients (APIs), especially antiviral compounds against the influenza A (H1N1) virus. It is also used in the synthesis of glucocorticoid receptor agonists for the treatment of inflammation. In addition, the presence of chloro and fluorine substituents in 3-chloro-5-fluoroaniline allows for further functionalisation such as palladium-catalysed carbon-carbon coupling and nucleophilic aromatic substitution.
Safety
| Symbol(GHS) |   GHS06,GHS08 |
| Signal word | Warning |
| Hazard statements | H302-H311-H315-H319-H332-H373 |
| Precautionary statements | P260-P280-P304+P340-P305+P351+P338-P405-P501a |
| Hazard Codes | Xn,T |
| Risk Statements | 36/37/38-20/21/22-23/24/25-22 |
| Safety Statements | 36/37/39-26-45 |
| RIDADR | 2810 |
| Hazard Note | Toxic |
| HazardClass | 6.1 |
| HS Code | 29214200 |
