6-Chloropyridine-2-carboxylic acid , 97% , 4684-94-0

Synonym(s):
6-Chloropicolinic acid

CAS NO.：4684-94-0

Empirical Formula: C6H4ClNO2

Molecular Weight: 157.55

MDL number: MFCD00155390

EINECS: 628-517-2

PRODUCT Properties

• Melting point: 190-191°C
• Boiling point: 241.15°C (rough estimate)
• Density: 1.3768 (rough estimate)
• refractive index: 1.5870 (estimate)
• storage temp.: Keep in dark place,Sealed in dry,Room Temperature
• solubility: DMSO (Slightly), Methanol
• pka: 3.27±0.10(Predicted)
• form: Crystalline Powder
• color: White to cream to tan
• Water Solubility: 3.40g/L(temperature not stated)
• λmax: 294nm(EtOH)(lit.)
• BRN: 115849
• InChIKey: ZLKMOIHCHCMSFW-UHFFFAOYSA-N
• CAS DataBase Reference: 4684-94-0(CAS DataBase Reference)
• EPA Substance Registry System: 6-Chloropicolinic acid (4684-94-0)

Description and Uses

6-Chloropyridine-2-carboxylic Acid is an intermediate of Sorafenib b(S676850), a multiple kinase inhibitor targeting both RAF kinase and receptor tyrosine kinases that promote angiogensis. Antineoplastic.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H303-H315-H319-H335-H401
• Precautionary statements: P261-P305+P351+P338-P280a-P304+P340-P405-P501a-P264-P273-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P501
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 2
• RTECS: TJ7535000
• HazardClass: IRRITANT
• HS Code: 29339900