o-Chlorophenol , CP , 95-57-8
Synonym(s):
2-Chloro-1-hydroxybenzene;2-Chlorophenol
CAS NO.：95-57-8
Empirical Formula: C6H5ClO
Molecular Weight: 128.56
MDL number: MFCD00002159
EINECS: 202-433-2
PRODUCT Properties
| Melting point: | 8 °C (lit.) |
| Boiling point: | 175-176 °C (lit.) |
| Density | 1.241 g/mL at 25 °C (lit.) |
| vapor pressure | 13.3 hPa (50 °C) |
| refractive index | n |
| Flash point: | 147 °F |
| storage temp. | under inert gas (Argon) |
| solubility | alcohol: freely soluble |
| pka | 8.49(at 25℃) |
| color | Clear Colourless to Pale Orange |
| Water Solubility | 28.5 g/L (20 ºC) |
| Merck | 14,2154 |
| BRN | 1905114 |
| Henry's Law Constant | 6.44 x 10-6 atm?m3/mol at 20 °C (Sheikheldin et al., 2001) |
| Dielectric constant | 8.2（19℃） |
| Stability: | Stable. Hygroscopic. Combustible. Incompatible with oxidizing agents, acid anhydrides, acid chlorides. |
| InChIKey | ISPYQTSUDJAMAB-UHFFFAOYSA-N |
| LogP | 2.18 at 20℃ |
| CAS DataBase Reference | 95-57-8(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Chlorophenol(95-57-8) |
| EPA Substance Registry System | o-Chlorophenol (95-57-8) |
Description and Uses
All have a characteristic odor. Odor threshold =1.24 ppm (pure). Molecular weight (all isomers) =128.56.m-isomer
Colorless (in pure state) to pink or amber (technical grade,due to impurities) crystalline solid or liquid. Boilingpoint =214℃; Freezing/Melting point =32.8℃; Specificgravity (H2O:1) =1.245; Vapor pressure =5 mmHg at70℃; Flash point =112℃. Solubility in water=2.6-2.8.5% at 20℃. Hazard Identification (based onNFPA 704 M Rating System): Health 2, Flammability 0,Reactivity 0.
o-isomerWhite crystalline (needle-like) solid. Boilingpoint =175.6℃; Freezing/Melting point =9.3-9.8℃;Specific gravity (H2O:1) =1.3; Vapor pressure, Pa at20℃ =230; Relative vapor density (air =1) =4.4; Flashpoint =64℃ (cc). Hazard Identification (based on NFPA704 M Rating System): Health 3, Flammability 2,Reactivity 0. Solubility in water =2.7% at 20℃.p-isomer
White to straw-colored, needle-like crystalline solid.Boiling point =218℃; Freezing/Melting point =43℃;Vapor pressure =10 mmHg at 20℃; Vapor density (air=1) =4.44; Flash point = 121℃ (cc). HazardIdentification (based on NFPA 704 M Rating System):Health 3, Flammability 1, Reactivity 0. Solubility inwater =2.71% at 20℃.
2-Chlorophenol is used to synthesize various organic intermediates and compounds including several polycyclic aromatic hydrocarbons and pharmacologically active molecules. It is used as a precursor to synthesize polychlorinated dibenzo p-dioxins and dibenzofurans (PCDD/Fs).
Safety
| Symbol(GHS) |    GHS05,GHS06,GHS09 |
| Signal word | Danger |
| Hazard statements | H302-H311+H331-H314-H411 |
| Precautionary statements | P273-P280-P301+P312-P303+P361+P353-P304+P340+P310-P305+P351+P338 |
| Hazard Codes | Xn,N,T,F |
| Risk Statements | 20/21/22-51/53-39/23/24/25-23/24/25-11 |
| Safety Statements | 28-61-28A-45-36/37-16-7 |
| RIDADR | UN 2021 6.1/PG 3 |
| WGK Germany | 2 |
| RTECS | SK2625000 |
| F | 9 |
| Autoignition Temperature | 550 °C |
| TSCA | Yes |
| HazardClass | 6.1 |
| PackingGroup | III |
| HS Code | 29081000 |
| Hazardous Substances Data | 95-57-8(Hazardous Substances Data) |
| Toxicity | LD50 orally in rats: 0.67 g/kg (Deichmann) |
