D-Cycloserine , 98% , 68-41-7

Synonym(s):
(R)-4-Amino-3-isoxazolidone;D-Cycloserine;4-Amino-3-isoxazolidinone

CAS NO.：68-41-7

Empirical Formula: C3H6N2O2

Molecular Weight: 102.09

MDL number: MFCD00005353

EINECS: 200-688-4

PRODUCT Properties

• Melting point: 147 °C (dec.)(lit.)
• alpha: 111 º (C=5, 2N NaOH)
• Boiling point: 191.38°C (rough estimate)
• Density: 1.3516 (rough estimate)
• refractive index: 1.5110 (estimate)
• storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• solubility: water: soluble50mg/mL, clear, colorless to light yellow
• pka: pKa 4.5 (Uncertain)
• form: powder
• color: white to off-white
• optical activity: [α]20/D +115.0±5.0°, c = 2% in H2O
• Water Solubility: SOLUBLE
• Sensitive: Air Sensitive
• Merck: 14,2751
• BRN: 80798
• BCS Class: 3/1
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.

Description and Uses

D-Cycloserine (68-41-7) is a partial agonist at the glycine modulatory site of NMDA glutamatergic receptors.1?Blocks kainate-induced seizures2?and displays anticonvulsant effects3?in rat models. D-Cycloserine facilitates synaptic plasticity but impairs glutamatergic neurotransmission in rat hippocampal slices.4?Second-line drug for the treatment of tuberculosis. ?Enhances activity-dependent plasticity in human adults.5

antibacterial (tuberculostatic)

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P271-P261-P280
• Hazard Codes: Xn
• Risk Statements: 5-20
• Safety Statements: 38-36/37-24/25
• WGK Germany: 2
• RTECS: NY2975000
• F: 10-23
• HS Code: 29419090