Chlorhexidine diacetate salt hydrate , 98% , 56-95-1

Synonym(s):
Chlorhexidine diacetate;Chlorhexidine diacetate salt

CAS NO.：56-95-1

Empirical Formula: C26H38Cl2N10O4

Molecular Weight: 625.55

MDL number: MFCD00012532

EINECS: 200-302-4

PRODUCT Properties

• Melting point: 153-156°C
• storage temp.: 2-8°C
• solubility: H₂O: 15 mg/mL, clear
• form: Solid
• color: White to Almost white
• Water Solubility: 1.9 g/100 mL (20 ºC)
• Merck: 14,2091
• InChIKey: GHXZTYHSJHQHIJ-UHFFFAOYSA-N
• LogP: 4.931 (est)

Description and Uses

Chlorhexidine Diacetate is a disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque. Chlorhexidine is a cationic broad-spectrum antimicrobial agent belonging to the bis(biguanide) family. Its mechanism of action involves destabilization of the outer bacterial membrane. It is effective on both Gram-positive and Gram-negative bacteria, although it is less effective with some Gram-negative bacteria. It has both bactericidal and bacteriostatic mechanisms of action. Aqueous solutions of chlorhexidine are most stable within the pH range of 5-8. Above pH 8.0 chlorhexidine base is precipitated and in more acid conditions there is gradual deterioration of activity because the compound is less stable. Chlorhexidine is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs.

Safety

• Symbol(GHS): GHS07,GHS08,GHS09
• Signal word: Warning
• Hazard statements: H302-H315-H319-H371-H410
• Precautionary statements: P260-P273-P301+P312-P302+P352-P305+P351+P338-P308+P311
• Hazard Codes: Xn,Xi,N
• Risk Statements: 22-43-36/37/38-50/53
• Safety Statements: 36/37-36-26-61-60
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 3
• RTECS: DU1930000
• F: 8-10
• HazardClass: 9
• PackingGroup: III
• HS Code: 2925294500
• Toxicity: LD50 orally in mice: 2 g/kg (Davies)