Chlorotrimethylsilane , ≥99.0%(GC) , 75-77-4
Synonym(s):
TMSCl;Chlorotrimethylsilane;Trimethylsilyl chloride;TMCS;Trimethylchlorosilane
CAS NO.：75-77-4
Empirical Formula: C3H9ClSi
Molecular Weight: 108.64
MDL number: MFCD00000502
EINECS: 200-900-5
PRODUCT Properties
| Melting point: | −40 °C(lit.) |
| Boiling point: | 57 °C(lit.) |
| Density | 0.857 g/mL at 25 °C |
| vapor density | 3.7 (vs air) |
| vapor pressure | 100 mm Hg ( 25 °C) |
| refractive index | n |
| Flash point: | 104 °F |
| storage temp. | Store below +30°C. |
| solubility | Miscible with ether, benzene, diethylether and perchloroethylene. |
| form | Liquid |
| Specific Gravity | 0.8536 (27℃) |
| color | Clear colorless |
| explosive limit | 1.5-46%(V) |
| Water Solubility | REACTS |
| Hydrolytic Sensitivity | 8: reacts rapidly with moisture, water, protic solvents |
| Sensitive | Moisture Sensitive |
| BRN | 1209232 |
| Stability: | Stable. Highly flammable - note low flash point. Reacts violently with water. Incompatible with water, moisture, strong oxidizing agents, strong acids, strong bases, aldehydes, alcohols, amines, esters, ketones. |
| InChIKey | IJOOHPMOJXWVHK-UHFFFAOYSA-N |
| CAS DataBase Reference | 75-77-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Silane, chlorotrimethyl-(75-77-4) |
| EPA Substance Registry System | Trimethylchlorosilane (75-77-4) |
Description and Uses
Chlorotrimethylsilane is a valuable reagent for the protection of the hydroxyl function in organic synthesis. It should be distilled from calciumhydride (or tributylamine) under nitrogen before use,and stored and weighed under nitrogen. Use of the reagent without purification has been reported to lead to explosions. Chlorotrimethylsilane may contain dichlorodimethylsilane as an impurity. This may be removed before distillation by very cautious treatment with a small amount of water，which hydrolyses the dichloro compound more rapidly. Excess chlorotrimethylsilane in a reaction mixture may be destroyed by the very careful addition of aqueous sodium hydrogencarbonate solution.
Chlorotrimethylsilane is a typical Silane Blocking Agent, which can protect or deprotect functional groups selectively. It have been used in the preparation of volatile derivatives of a wide range of compounds for GC analysis, and used for silylation and as a protection group in the process of various organic synthesis. It is used in the production of trimethylsilyl halides, pseudohalides and various organic silicon compounds. It is also used to produce hexamethyldisilane by reduction.
Safety
| Symbol(GHS) |    GHS02,GHS05,GHS06 |
| Signal word | Danger |
| Hazard statements | H225-H301+H331-H312-H314 |
| Precautionary statements | P210-P233-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 |
| Hazard Codes | T,F,C,Xn |
| Risk Statements | 20/21-36/38-34-21-14-11-37-35-19-40-10-67-20/21/22-52 |
| Safety Statements | 26-36/37/39-45-16-36/37-7/9 |
| RIDADR | UN 2924 3/PG 2 |
| WGK Germany | 2 |
| RTECS | VV2710000 |
| F | 10-21 |
| Autoignition Temperature | 752 °F |
| Hazard Note | Highly Flammable/Corrosive/Moisture Sensitive |
| TSCA | Yes |
| HazardClass | 3 |
| PackingGroup | II |
| HS Code | 29310095 |
| Hazardous Substances Data | 75-77-4(Hazardous Substances Data) |
| Toxicity | LD50 orally in Rabbit: 4868 mg/kg LD50 dermal Rabbit 1530 mg/kg |
