Home Categories Chemical Reagents Chlorotrimethylsilane
A2289612

Chlorotrimethylsilane , >98.0%(GC) , 75-77-4

Synonym(s):
TMSCl;Chlorotrimethylsilane;Trimethylsilyl chloride;TMCS;Trimethylchlorosilane

CAS NO.:75-77-4

Empirical Formula: C3H9ClSi

Molecular Weight: 108.64

MDL number: MFCD00000502

EINECS: 200-900-5

Update time: 2022-07-08

PRODUCT Properties

Melting point: −40 °C(lit.)
Boiling point: 57 °C(lit.)
Density  0.857 g/mL at 25 °C
vapor density  3.7 (vs air)
vapor pressure  100 mm Hg ( 25 °C)
refractive index  n20/D 1.500
Flash point: 104 °F
storage temp.  Store below +30°C.
solubility  Miscible with ether, benzene, diethylether and perchloroethylene.
form  Liquid
Specific Gravity 0.8536 (27℃)
color  Clear colorless
explosive limit 1.5-46%(V)
Water Solubility  REACTS
Hydrolytic Sensitivity 8: reacts rapidly with moisture, water, protic solvents
Sensitive  Moisture Sensitive
BRN  1209232
Stability: Stable. Highly flammable - note low flash point. Reacts violently with water. Incompatible with water, moisture, strong oxidizing agents, strong acids, strong bases, aldehydes, alcohols, amines, esters, ketones.
InChIKey IJOOHPMOJXWVHK-UHFFFAOYSA-N

Description and Uses

Chlorotrimethylsilane is a valuable reagent for the protection of the hydroxyl function in organic synthesis. It should be distilled from calciumhydride (or tributylamine) under nitrogen before use,and stored and weighed under nitrogen. Use of the reagent without purification has been reported to lead to explosions. Chlorotrimethylsilane may contain dichlorodimethylsilane as an impurity. This may be removed before distillation by very cautious treatment with a small amount of water,which hydrolyses the dichloro compound more rapidly. Excess chlorotrimethylsilane in a reaction mixture may be destroyed by the very careful addition of aqueous sodium hydrogencarbonate solution.

Chlorotrimethylsilane is a typical Silane Blocking Agent, which can protect or deprotect functional groups selectively. It have been used in the preparation of volatile derivatives of a wide range of compounds for GC analysis, and used for silylation and as a protection group in the process of various organic synthesis. It is used in the production of trimethylsilyl halides, pseudohalides and various organic silicon compounds. It is also used to produce hexamethyldisilane by reduction.

Safety

Symbol(GHS) 
GHS02,GHS05,GHS06
Signal word  Danger
Hazard statements  H225-H301+H331-H312-H314
Precautionary statements  P210-P233-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
Hazard Codes  T,F,C,Xn
Risk Statements  20/21-36/38-34-21-14-11-37-35-19-40-10-67-20/21/22-52
Safety Statements  26-36/37/39-45-16-36/37-7/9
RIDADR  UN 2924 3/PG 2
WGK Germany  2
RTECS  VV2710000
10-21
Autoignition Temperature 752 °F
Hazard Note  Highly Flammable/Corrosive/Moisture Sensitive
TSCA  Yes
HazardClass  3
PackingGroup  II
HS Code  29310095
Toxicity LD50 orally in Rabbit: 4868 mg/kg LD50 dermal Rabbit 1530 mg/kg

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