A2280712
m-Chloroaniline , 99% , 108-42-9
Synonym(s):
3-Chloroaniline;m-Chloroaniline
CAS NO.：108-42-9
Empirical Formula: C6H6ClN
Molecular Weight: 127.57
MDL number: MFCD00007765
EINECS: 203-581-0
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | −11-−9 °C(lit.) |
| Boiling point: | 95-96 °C11 mm Hg(lit.) |
| Density | 1.206 g/mL at 25 °C(lit.) |
| vapor pressure | 1 mm Hg ( 63.5 °C) |
| refractive index | n |
| Flash point: | 255 °F |
| storage temp. | Store below +30°C. |
| solubility | 6.2g/l |
| form | Liquid |
| pka | 3.46(at 25℃) |
| color | Clear pale yellow to brown |
| PH | 7.3 (H2O)(saturated aqueous solution) |
| Odor | Characteristic odour |
| Water Solubility | 6.8 g/L (20 ºC) |
| Decomposition | 190°C |
| Merck | 14,2118 |
| BRN | 605969 |
| Dielectric constant | 13.4（19℃） |
| Stability: | Material darkens in storage with no loss in purity, Material Darkens In Storage |
| LogP | 0.77-2.03 at 25-30℃ |
| CAS DataBase Reference | 108-42-9(CAS DataBase Reference) |
| NIST Chemistry Reference | m-Chloroaniline(108-42-9) |
| EPA Substance Registry System | m-Chloroaniline (108-42-9) |
Description and Uses
m-Chloroaniline is used as an intermediate for pesticides, pharmaceuticals, and dyes. It is produced by lowpressure hydrogenation of 3-chloronitrobenzene in the liquid phase with noble metal and/or noble metal sulfide catalysts. The addition of metal oxides to the reaction helps avoid dehalogenation. The yield is approximately 98 %.
3-Chlorobenzenamine is used in the synthesis of pyrimidoazepine analogs as serotonin 5-HT2A and 5-HT2C receptor ligands for the treatment of obesity. Also used in the synthesis of novel COX-2 inhibito rs.
Safety
| Symbol(GHS) |    GHS06,GHS08,GHS09 |
| Signal word | Danger |
| Hazard statements | H301+H311-H317-H319-H330-H373-H410 |
| Precautionary statements | P273-P280-P302+P352+P312-P304+P340+P310-P305+P351+P338-P314 |
| Hazard Codes | T,N |
| Risk Statements | 23/24/25-33-50/53 |
| Safety Statements | 28-36/37-45-60-61-28A |
| RIDADR | UN 2019 6.1/PG 2 |
| WGK Germany | 2 |
| RTECS | BX0350000 |
| F | 8-10-23 |
| Autoignition Temperature | 705 °C |
| Hazard Note | Toxic |
| TSCA | Yes |
| HazardClass | 6.1 |
| PackingGroup | II |
| HS Code | 29214210 |
| Hazardous Substances Data | 108-42-9(Hazardous Substances Data) |
| Toxicity | LD50 orally in Rabbit: 256 mg/kg LD50 dermal Rat 250 mg/kg |
