4-Chloromethyl-5-methyl-1,3-dioxol-2-one , 98% , 80841-78-7

CAS NO.：80841-78-7

Empirical Formula: C5H5ClO3

Molecular Weight: 148.54

MDL number: MFCD07787494

EINECS: 617-178-6

PRODUCT Properties

• Boiling point: >90℃/2mm
• Density: 1.362±0.06 g/cm3(Predicted)
• refractive index: 1.4760-1.4820
• Flash point: 129 °C
• storage temp.: Keep in dark place,Sealed in dry,Room Temperature
• solubility: Chloroform (Slightly), Methanol (Slightly)
• form: liquid
• Specific Gravity: 1.36
• color: Colorless to Light yellow to Light orange
• BRN: 4798926
• InChI: InChI=1S/C5H5ClO3/c1-3-4(2-6)9-5(7)8-3/h2H2,1H3
• InChIKey: QCLFSYYUWPUWQR-UHFFFAOYSA-N
• SMILES: CC1=C(OC(=O)O1)CCl
• CAS DataBase Reference: 80841-78-7(CAS DataBase Reference)

Description and Uses

4-Chloromethyl-5-methyl-1,3-dioxol-2-one is a useful branch side chain for synthetic penicillin esters such as Lenampicillin, Mecillinam, etc. It can improve the stability and absorption of drugs, increase biological activity, and reduce side effects. It is also used to prepare amine drugs, such as Norfloxacin prodrug. In the prior art, the primary method for synthesizing 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one is a chlorination reaction of chlorine gas or N-chlorosuccinimide. 

4-Chloromethyl-5-methyl-1,3-dioxol-2-one is an important reagent in the preparation of angiotensin II receptor antagonist such as Olmesratan Medoxomil (O550000). It is also used in the preparation of prodrugs of ampicillin.

Safety

• Symbol(GHS): GHS07,GHS06
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335-H301
• Precautionary statements: P280a-P301+P310a-P405-P501a-P261-P305+P351+P338-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
• Hazard Codes: Xn
• Risk Statements: 22-36/37/38
• Safety Statements: 26
• WGK Germany: 3
• HS Code: 29329990